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MedKoo Cat#: 571073 | Name: Chromonar HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chromonar is a vasodilatory compound that exhibits calcium channel blocking activity. It has been shown to inhibit calcium influx in smooth muscle and cardiac tissue, contributing to its antihypertensive and antianginal effects. Chromonar has also been reported to block ATP-sensitive potassium (K_ATP) channels in cardiac cells, potentially altering cardiac electrophysiology. In preclinical studies, it demonstrated dose-dependent negative inotropic and chronotropic effects. For instance, in isolated rat hearts, Chromonar at 10–100 μM significantly reduced left ventricular pressure and heart rate.

Chemical Structure

Chromonar HCl
Chromonar HCl
CAS#655-35-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 571073

Name: Chromonar HCl

CAS#: 655-35-6 (HCl)

Chemical Formula: C20H28ClNO5

Exact Mass: 397.1656

Molecular Weight: 397.90

Elemental Analysis: C, 60.37; H, 7.09; Cl, 8.91; N, 3.52; O, 20.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
804-10-4 (free base) 655-35-6 (HCl)
Synonym
Chromonar hydrochloride; chromonar HCl; ntenkordin Intenkordin hydrochloride; Intensain; Intensain hydrochloride; Intercordin; Interkordin; NSC 110430;
IUPAC/Chemical Name
Acetic acid, ((3-(2-(diethylamino)ethyl)-4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy)-, ethyl ester, hydrochloride
InChi Key
KSQIAZKOUOEHSA-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H27NO5.ClH/c1-5-21(6-2)11-10-17-14(4)16-9-8-15(12-18(16)26-20(17)23)25-13-19(22)24-7-3;/h8-9,12H,5-7,10-11,13H2,1-4H3;1H
SMILES Code
O=C(OCC)COC1=CC=C(C(O2)=C1)C(C)=C(CCN(CC)CC)C2=O.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 397.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bell H, Azarnoff DL, Dunn M. Treatment of angina pectoris with chromonar hydrochloride. Clin Pharmacol Ther. 1968 Jan-Feb;9(1):40-4. PubMed PMID: 4966194. 2: Cacioppo S, Cacioppo JT. Dynamic spatiotemporal brain analyses using high-performance electrical neuroimaging, Part II: A step-by-step tutorial. J Neurosci Methods. 2015 Dec 30;256:184-97. doi: 10.1016/j.jneumeth.2015.09.004. Epub 2015 Sep 10. PubMed PMID: 26363189. 3: Fiedler VB. Chromonar and coronary steal. Am J Cardiol. 1981 Nov;48(5):978-80. PubMed PMID: 7304449. 4: Weiss HR, Winbury MM. Nitroglycerin and chromonar on small-vessel blood content of the ventricular walls. Am J Physiol. 1974 Apr;226(4):838-43. PubMed PMID: 4207222. 5: Keelan KE, Gross GJ, Brooks HL, Warltier DC. Contrasting effects of pharmacologic vasodilation on true collateral and overlap perfusion in ischemic myocardium. Gen Pharmacol. 1984;15(6):471-7. PubMed PMID: 6526259. 6: Yamaoka T, Nakamachi H, Miyata K. Studies on the characteristics of carbochromen hydrochloride crystals. II. Polymorphism and cracking in the tablets. Chem Pharm Bull (Tokyo). 1982 Oct;30(10):3695-700. PubMed PMID: 7160015. 7: Aporti F, Leon A, Toffano G. Anti-phosphodiesterase activity of the coronary dilating agent hydrochloride carbocromene. Pharmacol Res Commun. 1975 Jun;7(3):289-97. PubMed PMID: 167386. 8: Gross GJ, Diemer MJ, Warltier DC, Hardman HF. Relaxation of potassium-depolarized canine, bovine and porcine large coronary arteries by nitroglycerin, chromonar and two dihydropyridine calcium antagonists. Gen Pharmacol. 1981;12(3):199-204. PubMed PMID: 6786956. 9: Martin YC, Wiegand RG. Metabolism and excretion of chromonar and its metabolite in dog and man. J Pharm Sci. 1970 Sep;59(9):1313-8. PubMed PMID: 5469797. 10: Warltier DC, Hardman HF, Brooks HL, Gross GJ. Transmural gradient of coronary blood flow following dihydropyridine calcium antagonists and other vasodilator drugs. Basic Res Cardiol. 1983 Nov-Dec;78(6):644-53. PubMed PMID: 6661160. 11: White CW, Holida MD, Marcus ML. Effects of acute atrial fibrillation on the vasodilator reserve of the canine atrium. Cardiovasc Res. 1986 Sep;20(9):683-9. PubMed PMID: 3791359. 12: Bing RJ, Bender SR, Dunn MI, Fry GA, Fuller WM, Liu SC, Miller HS, Moses JW, Ritzmann LW, Segal JP, Shugoll GI, Tillmanns H, Wallace A. Antianginal effects of chromonar. A combined investigation. Clin Pharmacol Ther. 1974 Jul;16(1):4-13. PubMed PMID: 4210514. 13: Mallion JM, Denis B, Rival M. [Clinical study of carbocromen (chromonar), new coronary vasodilator]. J Med Lyon. 1969 Mar 5;50(160):411-3. French. PubMed PMID: 5784251. 14: Weiss HR, Howe BB, Winbury MM. Differential effects of chromonar and nitroglycerin on intramyocardial oxygen tension. Eur J Pharmacol. 1973 Jun;22(3):249-55. PubMed PMID: 4205276. 15: el Walily AF, elSayed MA, Barary MH, Sabry SM. Determination of the chromonar hydrochloride metabolite in urine using derivative spectroscopy. J Pharm Biomed Anal. 1991;9(5):417-20. PubMed PMID: 1932277. 16: Gross GJ, Buck JD, Warltier DC, Hardman HF. Separation of overlap and collateral perfusion of ischemic canine myocardium: important considerations in the analysis of vasodilator-induced coronary steal. J Cardiovasc Pharmacol. 1982 Mar-Apr;4(2):254-63. PubMed PMID: 6175809. 17: Warltier DC, Gross GJ, Brooks HL. Coronary steal-induced increase in myocardial infarct size after pharmacologic coronary vasodilation. Am J Cardiol. 1980 Jul;46(1):83-90. PubMed PMID: 7386397. 18: Kleinert HD, Weiss HR. Microregional blood flow and high energy phosphates under conditions of high O2 supply in left ventricular subendocardium. Arch Int Physiol Biochim. 1983 Sep;91(3):145-57. PubMed PMID: 6198984. 19: Talafih K, Briden KL, Weiss HR. Thyroxine-induced hypertrophy of the rabbit heart. Effect on regional oxygen extraction, flow, and oxygen consumption. Circ Res. 1983 Mar;52(3):272-9. PubMed PMID: 6218937. 20: Klaus W, Güttler K. Influence of carbocromen on some metabolic parameters of isolated working guinea pig hearts. Adv Myocardiol. 1982;3:571-5. PubMed PMID: 7170442.

View History

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