Perthane | CAS# 72-56-0 | Pesticide

MedKoo Cat#: 571066 | Name: Perthane

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Perthane is the diethyl derivative of common pesticide DDD. Perthane may prevent the formation of spontaneous mammary carcinoma, and also may causes adrenocortical atrophy in humans.

Chemical Structure

Perthane

CAS#72-56-0

Theoretical Analysis

MedKoo Cat#: 571066

Name: Perthane

CAS#: 72-56-0

Chemical Formula: C18H20Cl2

Exact Mass: 306.0942

Molecular Weight: 307.26

Elemental Analysis: C, 70.36; H, 6.56; Cl, 23.08

Price and Availability

Size	Price	Availability	Quantity
250mg	USD 170.00

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Synonym

Perthane

IUPAC/Chemical Name

1,1-Dichloro-2,2-bis(4-ethylphenyl)ethane

InChi Key

QFMDFTQOJHFVNR-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H20Cl2/c1-3-13-5-9-15(10-6-13)17(18(19)20)16-11-7-14(4-2)8-12-16/h5-12,17-18H,3-4H2,1-2H3

SMILES Code

CCC1=CC=C(C(C2=CC=C(CC)C=C2)C(Cl)Cl)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Perthane is the diethyl derivative of common pesticide DDD.

In vitro activity:

TBD

In vivo activity:

TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 307.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1: Raina R, Hall P. Comparison of gas chromatography-mass spectrometry and gas chromatography-tandem mass spectrometry with electron ionization and negative- ion chemical ionization for analyses of pesticides at trace levels in atmospheric samples. Anal Chem Insights. 2008 Sep 9;3:111-25. doi: 10.4137/aci.s1005. PMID: 19609395; PMCID: PMC2701172. 2: Axmon A, Hagmar L, Jönsson BA. Rapid decline of persistent organochlorine pollutants in serum among young Swedish males. Chemosphere. 2008 Feb;70(9):1620-8. doi: 10.1016/j.chemosphere.2007.07.077. Epub 2007 Sep 12. PMID: 17845816. 3: Zhou Q, Ding Y, Xiao J, Liu G, Guo X. Investigation of the feasibility of TiO(2) nanotubes for the enrichment of DDT and its metabolites at trace levels in environmental water samples. J Chromatogr A. 2007 Apr 13;1147(1):10-6. doi: 10.1016/j.chroma.2007.02.081. Epub 2007 Feb 28. PMID: 17346719. 4: García-Repetto R, Giménez MP, Repetto M. New method for determination of ten pesticides in human blood. J AOAC Int. 2001 Mar-Apr;84(2):342-9. PMID: 11324596. 5: Najam AR, Korver MP, Williams CC, Burse VW, Needham LL. Analysis of a mixture of polychlorinated biphenyls and chlorinated pesticides in human serum by column fractionation and dual-column capillary gas chromatography with electron capture detection. J AOAC Int. 1999 Jan-Feb;82(1):177-85. PMID: 10028686. 6: Burse VW, McClure PC, Korver MP, Head SL, Needham LL. Potential compounds for monitoring method performance in the determination of selected organochlorine pesticides and polychlorinated biphenyls in human serum. J Anal Toxicol. 1990 May-Jun;14(3):143-5. doi: 10.1093/jat/14.3.143. PMID: 2165198. 7: Reuber MD. Histopathology of carcinomas of the liver in mice fed perthane. Tumori. 1980 Jun 30;66(3):277-83. doi: 10.1177/030089168006600301. PMID: 6255646. 8: Komissarenko VP, Chelnakova IS, Mikosha AS. Aktivnost' glutationreduktazy v nadpochechnikakh i pecheni sobak pri vvedenii O,P-DDD, pertana i AKTG [Activity of glutathione reductase in the adrenal glands and the liver of dogs after administration O,P-DDD, perthane and ACTH]. Probl Endokrinol (Mosk). 1978 Jan- Feb;24(1):95-8. Russian. PMID: 204922. 9: Nicholas ML, Powell DL, Williams TR, Bromund RH. Reference Raman spectra of DDT and five structurally related pesticides and of five pesticides containing the norbornen group. J Assoc Off Anal Chem. 1976 Jan;59(1):197-208. PMID: 1249035. 10: Krause RT. Determination of several chlorinated pesticides by the AOAC multiresidue method with additional quantitation of perthane after dehydrochlorination: collaborative study. J Assoc Off Anal Chem. 1973 May;56(3):721-7. PMID: 4779911. 11: Chau AS, Lanouette M. Confirmation of pesticide residue identity. II. Derivative formation in solid matrix for the confirmation of DDT, DDD, methoxychlor, perthane, cis- and trans-chlordane, heptachlor, and heptachlor epoxide pesticide residues by gas chromatography. J Assoc Off Anal Chem. 1972 Sep;55(5):1058-66. PMID: 5071861. 12: Krause RT. Quantitative dehydrochlorination of perthane residues and effect of alcoholic potassium hydroxide on other pesticides. J Assoc Off Anal Chem. 1972 Sep;55(5):1042-52. PMID: 5071859. 13: Halladay SC, Cahill WP, Ware GW. Synthesis of 14 C-labeled 1,1-dichloro-2,2-bis(p-ethylphenyl)ethane (Perthane) and related products. J Agric Food Chem. 1972 May-Jun;20(3):541-2. doi: 10.1021/jf60181a009. PMID: 5072302. 14: Komissarenko VP, Reznikov AG, Gordienko VM. Deĭstvie P,P-diétildifenildikhlorétana (pertana) na funktsiiu i struktury kory nadpochnykh zhelez morskikh svinok [The effect of P,P-diethyldiphenyldichlorethane (Perthane) on the function and structure of adrenal cortex in guinea pigs]. Probl Endokrinol (Mosk). 1968 Jul- Aug;14(4):90-5. Russian. PMID: 5734186. 15: WEISENFELD S, HECHT A, LEICHTER D, GOLDNER M. O,P'DDD IN THE TREATMENT OF ADVANCED MAMMARY CARCINOMA. Cancer. 1964 Oct;17:1258-66. doi: 10.1002/1097-0142(196410)17:10<1258::aid-cncr2820171007>3.0.co;2-3. PMID: 14236758. 16: LEONE LA, HAHN HB Jr, MELLETTE SJ. Studies of the effect of perthane on spontaneous and transplanted mammary carcinoma in the C3H mouse. Cancer Res. 1958 Nov;18(10):1161-6. PMID: 13596957. 17: NICHOLS J, KAYE S, LARSON PS. Barbituarte potentiating action of DDD and perthane. Proc Soc Exp Biol Med. 1958 Jun;98(2):239-42. doi: 10.3181/00379727-98-24002. PMID: 13554604. 18: Perthane, the Adrenal Cortex, and Cancer. Can Med Assoc J. 1958 Mar 1;78(5):357. PMID: 20325653; PMCID: PMC1829678. 19: Taliaferro I, Leone L. Inhibitory effect of perthane (2, 2-bis-[para- ethylphenyl]-1,1-dichloroethane) on adrenocortical function in human subjects. N Engl J Med. 1957 Oct 31;257(18):855-60. doi: 10.1056/NEJM195710312571803. PMID: 13477401. 20: FINNEGAN JK, HENNIGAR GR, SMITH RB Jr, LARSON PS, HAAG HB. Acute and chronic toxicity studies on 2,2-bis-(p-ethylphenyl)-1,1-dichloroethane (perthane). Arch Int Pharmacodyn Ther. 1955 Oct 15;103(4):404-18. PMID: 13283630.