ST-168 is a potent MEK/PI3K bifunctional inhibitor. ST-168 displays improved MEK1 and PI3K isoform inhibition. ST-168 demonstrated a 2.2-fold improvement in MEK1 inhibition and a 2.8-, 2.7-, 23-, and 2.5-fold improved inhibition toward the PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ isoforms, respectively, as compared to a previous lead ST-162 in in vitro enzymatic inhibition assays. ST-168 demonstrated superior tumoricidal efficacy over ST-162 in an A375 melanoma spheroid tumor model.
MedKoo Cat#: 407504
Name: ST-168
CAS#: Unknown
Chemical Formula: C41H44F5IN10O7
Exact Mass: 1010.2359
Molecular Weight: 1010.76
Elemental Analysis: C, 48.72; H, 4.39; F, 9.40; I, 12.56; N, 13.86; O, 11.08
The following data is based on the product molecular weight 1,010.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
