St 587 | CAS#15327-38-5 | sympathomimetic

MedKoo Cat#: 585221 | Name: St 587

Description:

WARNING: This product is for research use only, not for human or veterinary use.

St 587 is a clonidine derivative which is a selective alpha(1)-adrenoceptor stimulator with lipophilic properties.

Chemical Structure

St 587

CAS#15327-38-5

Theoretical Analysis

MedKoo Cat#: 585221

Name: St 587

CAS#: 15327-38-5

Chemical Formula: C10H10ClF3N4O3

Exact Mass: 326.0394

Molecular Weight: 326.66

Elemental Analysis: C, 36.77; H, 3.09; Cl, 10.85; F, 17.45; N, 17.15; O, 14.69

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

St 587; St587; St-587

IUPAC/Chemical Name

1H-Imidazol-2-amine, N-(2-chloro-5-(trifluoromethyl)phenyl)-4,5-dihydro-, mononitrate

InChi Key

DESQSCXTLOLOOG-UHFFFAOYSA-N

InChi Code

InChI=1S/C10H9ClF3N3.HNO3/c11-7-2-1-6(10(12,13)14)5-8(7)17-9-15-3-4-16-9;2-1(3)4/h1-2,5H,3-4H2,(H2,15,16,17);(H,2,3,4)

SMILES Code

FC(C1=CC=C(Cl)C(NC2=NCCN2)=C1)(F)F.O[N+]([O-])=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 326.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Menon MK, Kodama CK. Further studies on the ethanol antagonism exhibited by 2(2-chloro-5-trifluoromethyl phenylimino) imidazolidine (St 587). Life Sci. 1985 Dec 2;37(22):2091-8. PubMed PMID: 4068895. 2: Pichler L, Kobinger W. Alpha 2-adrenoceptor blocking properties of the alpha 1-selective agonist 2-(2-chloro-5-trifluoromethylphenylimino)imidazolidine (St 587). Arzneimittelforschung. 1985;35(1A):201-5. PubMed PMID: 2859026. 3: Badia A, Sallés J. Effects of St-587 on the alpha-adrenoceptors in the bisected rat vas deferens. J Pharm Pharmacol. 1989 Sep;41(9):612-6. PubMed PMID: 2573705. 4: Skarsfeldt T, Hyttel J. The St 587-induced flexor reflex in pithed rats: a model to evaluate central alpha 1-receptor blocking properties. Eur J Pharmacol. 1986 Jun 24;125(3):333-40. PubMed PMID: 2874039. 5: Pussinen R, Sirviö J. Effects of D-cycloserine, a positive modulator of N-methyl-D-aspartate receptors, and ST 587, a putative alpha-1 adrenergic agonist, individually and in combination, on the non-delayed and delayed foraging behaviour of rats assessed in the radial arm maze. J Psychopharmacol. 1999;13(2):171-9. PubMed PMID: 10475724. 6: Arnt J. Sertindole and several antipsychotic drugs differentially inhibit the discriminative stimulus effects of amphetamine, LSD and St 587 in rats. Behav Pharmacol. 1992 Feb;3(1):11-18. PubMed PMID: 11224097. 7: Loomis CW, Arunachalam KD. Intrathecal St-587: effects on nociceptive reflexes and blood pressure in the rat. J Pharmacol Exp Ther. 1992 Nov;263(2):428-35. PubMed PMID: 1331398. 8: Robbins TW. The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry. Psychopharmacology (Berl). 2002 Oct;163(3-4):362-80. Epub 2002 Aug 9. Review. PubMed PMID: 12373437. 9: Puumala T, Riekkinen P Sr, Sirviö J. Modulation of vigilance and behavioral activation by alpha-1 adrenoceptors in the rat. Pharmacol Biochem Behav. 1997 Apr;56(4):705-12. PubMed PMID: 9130297. 10: Jonge AD, van Meel JC, Timmermans PB, van Zwieten PA. A lipophilic, selective alpha1 -adrenoceptor agonist: 2-(2-chloro-5-trifluoromethylphenylimino)imida-zolidine (St 587). Life Sci. 1981 May 4;28(18):2009-16. PubMed PMID: 6113530. 11: Puumala T, Sirviö J, Ruotsalainen S, Riekkinen P Sr. Effects of St-587 and prazosin on water maze and passive avoidance performance of scopolamine-treated rats. Pharmacol Biochem Behav. 1996 Sep;55(1):107-15. PubMed PMID: 8870045. 12: Millan MJ, Rivet JM, Gobert A, Canton H, Veiga S, Bervoets K. 5-HT1A receptors and the tail-flick response. VI. Intrinsic alpha 1A-adrenoceptor antagonist properties can mask the actions of 5-HT1A receptor agonists in the spontaneous tail-flick paradigm. J Pharmacol Exp Ther. 1994 Apr;269(1):121-31. PubMed PMID: 7909555. 13: Pichler L, Kobinger W. Possible function of alpha 1-adrenoceptors in the CNS in anaesthetized and conscious animals. Eur J Pharmacol. 1985 Jan 8;107(3):305-11. PubMed PMID: 2984009. 14: Auclair MC, Vernimmen C, Lavau M, Lechat P. Dependence on extracellular potassium of the positive inotropic response to St 587, a selective alpha-1 adrenoceptor agonist, in Zucker rat heart ventricle. Life Sci. 1989;44(20):1475-82. PubMed PMID: 2566881. 15: Menon MK, Gordon LI, Fitten J. Interaction between clozapine and a lipophilic alpha 1-adrenergic agonist. Life Sci. 1988;43(22):1791-804. PubMed PMID: 2904633. 16: Tabernero A, Giraldo J, Vila E. Effect of NG-nitro-L-arginine methylester (L-NAME) on functional and biochemical alpha 1-adrenoceptor-mediated responses in rat blood vessels. Br J Pharmacol. 1996 Feb;117(4):757-63. PubMed PMID: 8646425; PubMed Central PMCID: PMC1909335. 17: Menon MK, Dinovo EC, Haddox VG. Modification of certain pharmacological effects of ethanol by lipophilic alpha-1 adrenergic agonists. Life Sci. 1987 Sep 28;41(13):1599-610. PubMed PMID: 2887999. 18: Puumala T, Greijus S, Narinen K, Haapalinna A, Riekkinen P Sr, Sirviö J. Stimulation of alpha-1 adrenergic receptors facilitates spatial learning in rats. Eur Neuropsychopharmacol. 1998 Feb;8(1):17-26. PubMed PMID: 9452936. 19: Riekkinen M, Kemppainen S, Riekkinen P Jr. Effects of stimulation of alpha 1-adrenergic and NMDA/glycine-B receptors on learning defects in aged rats. Psychopharmacology (Berl). 1997 May;131(1):49-56. PubMed PMID: 9181635. 20: Pawłowski L, Mazela H. Effects of antidepressant drugs, selective noradrenaline-or 5-hydroxytryptamine uptake inhibitors, on apomorphine-induced hypothermia in mice. Psychopharmacology (Berl). 1986;88(2):240-6. PubMed PMID: 3006113.