MedKoo Cat#: 561033 | Name: AZ617
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

AZ617 is a potent TLR4 agonist.

Chemical Structure

AZ617
AZ617
CAS# 2247439-36-5 (free acid)

Theoretical Analysis

MedKoo Cat#: 561033

Name: AZ617

CAS#: 2247439-36-5 (free acid)

Chemical Formula: C40H38N4O4

Exact Mass: 638.2893

Molecular Weight: 638.77

Elemental Analysis: C, 75.21; H, 6.00; N, 8.77; O, 10.02

Price and Availability

Size Price Availability Quantity
25mg USD 550.00 2 Weeks
50mg USD 950.00 2 Weeks
100mg USD 1,650.00 2 Weeks
1g USD 5,450.00 2 Weeks
2g USD 8,650.00 2 Weeks
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Synonym
AZ617; AZ 617; AZ-617
IUPAC/Chemical Name
(4-{Cyclopentylcarbamoyl-[(1,5-diphenyl-1H-pyrazole-3-carbonyl)-indan-5-yl-amino]-methyl}-phenyl)-acetic acid
InChi Key
XHFSTLKGPORBNI-UHFFFAOYSA-N
InChi Code
InChI=1S/C40H38N4O4/c45-37(46)24-27-18-20-30(21-19-27)38(39(47)41-32-14-7-8-15-32)43(34-23-22-28-12-9-13-31(28)25-34)40(48)35-26-36(29-10-3-1-4-11-29)44(42-35)33-16-5-2-6-17-33/h1-6,10-11,16-23,25-26,32,38H,7-9,12-15,24H2,(H,41,47)(H,45,46)
SMILES Code
O=C(O)CC1=CC=C(C(C(NC2CCCC2)=O)N(C(C3=NN(C4=CC=CC=C4)C(C5=CC=CC=C5)=C3)=O)C6=CC7=C(CCC7)C=C6)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 638.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Twomey R, Graham S, Spina JS, Wu X, Dubé PE, Ferrebee C, Housley W. Utilizing a human TLR selective ligand in a humanized immune system mouse model to investigate human TLR4 signaling. J Biol Methods. 2023 Nov 20;10:jbm-10-e99010008. doi: 10.14440/jbm.2023.408. PMID: 38046987; PMCID: PMC10691501.