KAR425 | CAS#1809050-49-4 | antimalarial agent

MedKoo Cat#: 558209 | Name: KAR425

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KAR425 is a bipyrrole tambjamines with antimalarial activity against multidrug-resistant P. yoelii in mice.

Chemical Structure

KAR425

CAS#1809050-49-4

Theoretical Analysis

MedKoo Cat#: 558209

Name: KAR425

CAS#: 1809050-49-4

Chemical Formula: C19H27N3

Exact Mass: 297.2205

Molecular Weight: 297.45

Elemental Analysis: C, 76.72; H, 9.15; N, 14.13

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

KAR425; KAR 425; KAR-425

IUPAC/Chemical Name

N-[[4-Ethyl-3-methyl-5-(1H-pyrrol-2-yl)-2H-pyrrol-2-ylidene]methyl]-cycloheptanamine

InChi Key

UMOKUEQLTLBMFK-QGOAFFKASA-N

InChi Code

InChI=1S/C19H27N3/c1-3-16-14(2)18(22-19(16)17-11-8-12-20-17)13-21-15-9-6-4-5-7-10-15/h8,11-13,15,20-21H,3-7,9-10H2,1-2H3/b18-13+

SMILES Code

CC1=C(CC)C(C2=CC=CN2)=N/C1=C/NC3CCCCCC3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 297.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kancharla P, Kelly JX, Reynolds KA. Synthesis and Structure-Activity Relationships of Tambjamines and B-Ring Functionalized Prodiginines as Potent Antimalarials. J Med Chem. 2015 Sep 24;58(18):7286-309. doi: 10.1021/acs.jmedchem.5b00560. Epub 2015 Sep 10. PubMed PMID: 26305125.