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MedKoo Cat#: 461274 | Name: Dalvastatin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dalvastatin is a prodrug which converts to its open hydroxyacid form in the body. It acts as a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.

Chemical Structure

Dalvastatin
Dalvastatin
CAS#132100-55-1

Theoretical Analysis

MedKoo Cat#: 461274

Name: Dalvastatin

CAS#: 132100-55-1

Chemical Formula: C24H31FO3

Exact Mass: 386.2257

Molecular Weight: 386.50

Elemental Analysis: C, 74.58; H, 8.08; F, 4.92; O, 12.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Dalvastatin; RG 12561; RG-12561; RG12561;
IUPAC/Chemical Name
(4S,6R)-6-((E)-2-(4'-fluoro-3,3,3',5,5-pentamethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)vinyl)-4-hydroxytetrahydro-2H-pyran-2-one
InChi Key
VDSBXXDKCUBMQC-VUOWKATKSA-N
InChi Code
InChI=1S/C24H31FO3/c1-15-10-16(6-9-21(15)25)19-13-23(2,3)14-24(4,5)20(19)8-7-18-11-17(26)12-22(27)28-18/h6-10,17-18,26H,11-14H2,1-5H3/b8-7+/t17-,18-/m0/s1
SMILES Code
O=C1C[C@@H](O)C[C@H](/C=C/C2=C(C3=CC=C(F)C(C)=C3)CC(C)(C)CC2(C)C)O1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 386.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Won CM. Epimerization and hydrolysis of dalvastatin, a new hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Pharm Res. 1994 Jan;11(1):165-70. PubMed PMID: 8140049. 2: Amin D, Gustafson SK, Weinacht JM, Cornell SA, Neuenschwander K, Kosmider B, Scotese AC, Regan JR, Perrone MH. RG 12561 (dalvastatin): a novel synthetic inhibitor of HMG-CoA reductase and cholesterol-lowering agent. Pharmacology. 1993;46(1):13-22. PubMed PMID: 8434028. 3: Khetarpal VK, Storbeck LS, Wells D, Meacham RH Jr. Method for separation and determination of lactone and hydroxy acid forms of a new HMG CoA reductase inhibitor (RG 12561) in plasma. J Chromatogr. 1991 Jul 5;567(2):491-7. PubMed PMID: 1939482. 4: Ammon HL, Prasad SM, Kumar N. Structure of RG-12561 dichloromethane solvate and a diastereomer. Acta Crystallogr C. 1992 Apr 15;48 ( Pt 4):669-75. PubMed PMID: 1515102.