Golidocitinib, also known as AZD4205, is a novel potent and selective janus kinase 1 (JAK1) inhibitor. AZD4205 has good preclinical pharmacokinetics. Compound 21 displayed an enhanced antitumor activity in combination with an approved EGFR inhibitor, osimertinib, in a preclinical non-small-cell lung cancer (NSCLC) xenograft NCI-H1975 model.
MedKoo Cat#: 206848
Name: Golidocitinib HCl
CAS#: Golidocitinib HCl
Chemical Formula: C25H33Cl2N9O2
Exact Mass: 0.0000
Molecular Weight: 562.50
Elemental Analysis: C, 53.38; H, 5.91; Cl, 12.60; N, 22.41; O, 5.69
The following data is based on the product molecular weight 562.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
