MedKoo Cat#: 551020 | Name: ML198
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase. ML198 serves as a starting point to develop a novel approach towards small molecule treatment for patients suffering from Gaucher disease.

Chemical Structure

ML198
ML198
CAS#1380716-06-2

Theoretical Analysis

MedKoo Cat#: 551020

Name: ML198

CAS#: 1380716-06-2

Chemical Formula: C17H14N4O

Exact Mass: 290.1168

Molecular Weight: 290.33

Elemental Analysis: C, 70.33; H, 4.86; N, 19.30; O, 5.51

Price and Availability

Size Price Availability Quantity
25mg USD 450.00 2 Weeks
100mg USD 1,250.00 2 Weeks
250mg USD 2,450.00 2 Weeks
1g USD 4,250.00 2 Weeks
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Related CAS #
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Synonym
ML198; ML-198; ML 198; NCGC758; NCGC 758; NCGC-758;
IUPAC/Chemical Name
N-(4-Ethynylphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxamide
InChi Key
HVZPJBKUFRREQC-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H14N4O/c1-4-13-5-7-14(8-6-13)20-17(22)15-10-18-21-12(3)9-11(2)19-16(15)21/h1,5-10H,2-3H3,(H,20,22)
SMILES Code
O=C(C1=C2N=C(C)C=C(C)N2N=C1)NC3=CC=C(C#C)C=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 290.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Rogers S, Patnaik S, Schoenen F, Zheng W, Choi J, Motabar O, Southall N, Westbroek W, Goldin E, Sidransky E, Leister W, Marugan JJ, Aubé J. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase. 2012 Mar 27 [updated 2013 Mar 7]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK143537/ PubMed PMID: 23762943.