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MedKoo Cat#: 597798 | Name: AK-Toxin II

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AK-Toxin II is a host-specific toxin to Japanese white pear, produced by Alternaria kikuchiana.

Chemical Structure

AK-Toxin II
AK-Toxin II
CAS#85146-10-7

Theoretical Analysis

MedKoo Cat#: 597798

Name: AK-Toxin II

CAS#: 85146-10-7

Chemical Formula: C22H25NO6

Exact Mass: 399.1682

Molecular Weight: 399.44

Elemental Analysis: C, 66.15; H, 6.31; N, 3.51; O, 24.03

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
AK-Toxin II;
IUPAC/Chemical Name
(R,2E,4Z,6E)-8-((acetyl-L-phenylalanyl)oxy)-8-((S)-2-methyloxiran-2-yl)octa-2,4,6-trienoic acid
InChi Key
UKDOGRQIIQQZBO-ARSRSNJNSA-N
InChi Code
InChI=1S/C22H25NO6/c1-16(24)23-18(14-17-10-6-5-7-11-17)21(27)29-19(22(2)15-28-22)12-8-3-4-9-13-20(25)26/h3-13,18-19H,14-15H2,1-2H3,(H,23,24)(H,25,26)/b4-3-,12-8+,13-9+/t18-,19+,22-/m0/s1
SMILES Code
O=C(O[C@@H]([C@@]1(C)OC1)/C=C/C=C\C=C\C(O)=O)[C@H](CC2=CC=CC=C2)NC(C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 399.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kuroda H, Miyashita M, Irie H, Ueno T. Studies on the structure-toxicity relationship of AK-toxin, a host-specific toxin to Japanese white pear, produced by Alternaria kikuchiana: synthesis of methyl (4S,5R)-4-(N-acetylphenylalanyl)oxy-5,6-epoxy-5-methylhex-2(E)-enoate and its stereoisomers. Chem Pharm Bull (Tokyo). 1994 Jun;42(6):1328-30. PubMed PMID: 8069979. 2: Tanaka A, Tsuge T. Structural and functional complexity of the genomic region controlling AK-toxin biosynthesis and pathogenicity in the Japanese pear pathotype of Alternaria alternata. Mol Plant Microbe Interact. 2000 Sep;13(9):975-86. PubMed PMID: 10975654. 3: Wolpert TJ, Dunkle LD, Ciuffetti LM. Host-selective toxins and avirulence determinants: what's in a name? Annu Rev Phytopathol. 2002;40:251-85. Epub 2002 Feb 20. Review. PubMed PMID: 12147761.