MedKoo Cat#: 128948 | Name: ML10

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ML10 is a Plasmodium PI4Kβ and PKG inhibitor.

Chemical Structure

ML10
ML10
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128948

Name: ML10

CAS#: N/A

Chemical Formula: C26H30FN7O2S

Exact Mass: 523.2166

Molecular Weight: 523.63

Elemental Analysis: C, 59.64; H, 5.78; F, 3.63; N, 18.72; O, 6.11; S, 6.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
ML10; ML 10; ML-10
IUPAC/Chemical Name
N-(5-(3-(2-((cyclopropylmethyl)amino)pyrimidin-4-yl)-7-((dimethylamino)methyl)-6-methylimidazo[1,2-a]pyridin-2-yl)-2-fluorophenyl)methanesulfonamide
InChi Key
LDISLUXUWYPJIZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H30FN7O2S/c1-16-14-34-23(12-19(16)15-33(2)3)31-24(18-7-8-20(27)22(11-18)32-37(4,35)36)25(34)21-9-10-28-26(30-21)29-13-17-5-6-17/h7-12,14,17,32H,5-6,13,15H2,1-4H3,(H,28,29,30)
SMILES Code
FC1=CC=C(C=C1NS(=O)(C)=O)C2=C(N(C=C(C)C(CN(C)C)=C3)C3=N2)C4=NC(NCC5CC5)=NC=C4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 523.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Platon L, Baker DA, Ménard D. Modified Plasmodium falciparum Ring-Stage Survival Assay with ML10 Kinase Inhibitor. Antimicrob Agents Chemother. 2023 May 17;67(5):e0001723. doi: 10.1128/aac.00017-23. Epub 2023 Apr 26. PMID: 37098950; PMCID: PMC10190288. 2: Bauwens M, De Saint-Hubert M, Cleynhens J, Vandeputte C, Li J, Devos E. In vitro and in vivo comparison of 18F and 123I-labeled ML10 with 68Ga-Cys2-AnxA5 for molecular imaging of apoptosis. Q J Nucl Med Mol Imaging. 2013 Jun;57(2):187-200. Epub 2013 Feb 6. PMID: 23389693.