Diflubenzuron | CAS#35367-38-5 | insect growth regulator | chitin synthesis inhibitor

MedKoo Cat#: 540109 | Name: Diflubenzuron

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diflubenzuron is an insect growth regulator and chitin synthesis inhibitor. It inhibits growth of Tribolium, Anopheles, Ascaris and Haemonchus.

Chemical Structure

Diflubenzuron

CAS# 35367-38-5

Theoretical Analysis

MedKoo Cat#: 540109

Name: Diflubenzuron

CAS#: 35367-38-5

Chemical Formula: C14H9ClF2N2O2

Exact Mass: 310.0321

Molecular Weight: 310.68

Elemental Analysis: C, 54.12; H, 2.92; Cl, 11.41; F, 12.23; N, 9.02; O, 10.30

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 250.00	2 Weeks
1g	USD 550.00	2 weeks

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Related CAS #

No Data

Synonym

Diflubenzuron; Difluron; Dimilin; Duphacid

IUPAC/Chemical Name

N-((4-chlorophenyl)carbamoyl)-2,6-difluorobenzamide

InChi Key

QQQYTWIFVNKMRW-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H9ClF2N2O2/c15-8-4-6-9(7-5-8)18-14(21)19-13(20)12-10(16)2-1-3-11(12)17/h1-7H,(H2,18,19,20,21)

SMILES Code

O=C(NC(NC1=CC=C(Cl)C=C1)=O)C2=C(F)C=CC=C2F

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 310.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Effects of buprofezin and diflubenzuron on various developmental stages of Asian citrus psyllid, Diaphorina citri. Pest Manag Sci. 2012 Oct;68(10):1405-12. doi: 10.1002/ps.3323. Epub 2012 May 31. PubMed PMID: 22653617. 5: Ruan C, Zhao X, Liu C. Determination of diflubenzuron and chlorbenzuron in fruits by combining acetonitrile-based extraction with dispersive liquid-liquid microextraction followed by high-performance liquid chromatography. J Sep Sci. 2015 Sep;38(17):2931-7. doi: 10.1002/jssc.201401162. Epub 2015 Jul 15. PubMed PMID: 26097091. 6: Xia WK, Ding TB, Niu JZ, Liao CY, Zhong R, Yang WJ, Liu B, Dou W, Wang JJ. Exposure to diflubenzuron results in an up-regulation of a chitin synthase 1 gene in citrus red mite, Panonychus citri (Acari: Tetranychidae). Int J Mol Sci. 2014 Feb 28;15(3):3711-28. doi: 10.3390/ijms15033711. PubMed PMID: 24590130; PubMed Central PMCID: PMC3975363. 7: de Barros AL, de Souza VV, Navarro SD, Oesterreich SA, Oliveira RJ, Kassuya CA, Arena AC. Genotoxic and mutagenic effects of diflubenzuron, an insect growth regulator, on mice. J Toxicol Environ Health A. 2013;76(17):1003-6. doi: 10.1080/15287394.2013.830585. PubMed PMID: 24168035. 8: Tilak R, Verma AK, Wankhade UB. Effectiveness of Diflubenzuron in the control of houseflies. J Vector Borne Dis. 2010 Jun;47(2):97-102. PubMed PMID: 20539047. 9: Guidi V, Lüthy P, Tonolla M. Comparison between diflubenzuron and a Bacillus thuringiensis israelensis- and Lysinibacillus sphaericus-based formulation for the control of mosquito larvae in urban catch basins in Switzerland. J Am Mosq Control Assoc. 2013 Jun;29(2):138-45. PubMed PMID: 23923328. 10: Hsiao YL, Ho WH, Yen JH. Vertical distribution in soil column and dissipation in soil of benzoylurea insecticides diflubenzuron, flufenoxuron and novaluron and effect on the bacterial community. Chemosphere. 2013 Jan;90(2):380-6. doi: 10.1016/j.chemosphere.2012.07.032. Epub 2012 Aug 14. PubMed PMID: 22897835. 11: Bellinato DF, Viana-Medeiros PF, Araújo SC, Martins AJ, Lima JB, Valle D. Resistance Status to the Insecticides Temephos, Deltamethrin, and Diflubenzuron in Brazilian Aedes aegypti Populations. Biomed Res Int. 2016;2016:8603263. doi: 10.1155/2016/8603263. Epub 2016 Jun 21. PubMed PMID: 27419140; PubMed Central PMCID: PMC4932163. 12: Castro AA, Lacerda MC, Zanuncio TV, de S Ramalho F, Polanczyk RA, Serrão JE, Zanuncio JC. Effect of the insect growth regulator diflubenzuron on the predator Podisus nigrispinus (Heteroptera: Pentatomidae). Ecotoxicology. 2012 Jan;21(1):96-103. doi: 10.1007/s10646-011-0769-z. Epub 2011 Aug 21. PubMed PMID: 21858643. 13: Samuelsen OB. Persistence and Stability of Teflubenzuron and Diflubenzuron When Associated to Organic Particles in Marine Sediment. Bull Environ Contam Toxicol. 2016 Feb;96(2):224-8. doi: 10.1007/s00128-015-1707-1. Epub 2015 Dec 10. PubMed PMID: 26662043. 14: Kamal HA, Khater EI. The biological effects of the insect growth regulators; pyriproxyfen and diflubenzuron on the mosquito Aedes aegypti. J Egypt Soc Parasitol. 2010 Dec;40(3):565-74. PubMed PMID: 21268527. 15: de Barros AL, Cavalheiro GF, de Souza AV, Traesel GK, Anselmo-Franci JA, Kassuya CA, Arena AC. Subacute toxicity assessment of diflubenzuron, an insect growth regulator, in adult male rats. Environ Toxicol. 2016 Apr;31(4):407-14. doi: 10.1002/tox.22054. Epub 2014 Sep 30. PubMed PMID: 25266294. 16: Benze TP, Sakuragui MM, Zago LH, Fernandes MN. Subchronic exposure to diflubenzuron causes health disorders in neotropical freshwater fish, Prochilodus lineatus. Environ Toxicol. 2016 May;31(5):533-42. doi: 10.1002/tox.22065. Epub 2014 Oct 31. PubMed PMID: 25359229. 17: Kavur H, Deveci Ö, Boyacıoğlu H. [The effects of chitin synthesis inhibitor, diflubenzuron on the larvae of Culex pipiens (L.) and Culiseta longiareolata (Macquart) (Diptera: Culicidae)]. Turkiye Parazitol Derg. 2011;35(3):154-8. doi: 10.5152/tpd.2011.39. Turkish. PubMed PMID: 22203506. 18: Sun R, Wang Z, Li Y, Xiong L, Liu Y, Wang Q. Design, synthesis, and insecticidal evaluation of new benzoylureas containing amide and sulfonate groups based on the sulfonylurea receptor protein binding site for diflubenzuron and glibenclamide. J Agric Food Chem. 2013 Jan 23;61(3):517-22. doi: 10.1021/jf304468b. Epub 2013 Jan 10. PubMed PMID: 23305601. 19: Du P, Liu X, Gu X, Dong F, Xu J, Kong Z, Li Y, Zheng Y. Residue behaviour of six pesticides in button crimini during home canning. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(6):1081-8. doi: 10.1080/19440049.2014.910314. PubMed PMID: 24761834. 20: Sadanandane C, Boopathi Doss PS, Jambulingam P. Efficacy of three formulations of diflubenzuron, an insect growth regulator, against Culex quinquefasciatus Say, the vector of Bancroftian filariasis in India. Indian J Med Res. 2012 Nov;136(5):783-91. 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