Difenoconazole | CAS#119446-68-3 | 14-α demethylase inhibitor | ergosterol synthesis inhibitor | fungal cell wall formation inhibitor

MedKoo Cat#: 540107 | Name: Difenoconazole

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Difenoconazole is a 14-α demethylase inhibitor that inhibits ergosterol synthesis and fungal cell wall formation. It may inhibit aromatase.

Chemical Structure

Difenoconazole

CAS#119446-68-3

Theoretical Analysis

MedKoo Cat#: 540107

Name: Difenoconazole

CAS#: 119446-68-3

Chemical Formula: C19H17Cl2N3O3

Exact Mass: 405.0647

Molecular Weight: 406.26

Elemental Analysis: C, 56.17; H, 4.22; Cl, 17.45; N, 10.34; O, 11.81

Price and Availability

Size	Price	Availability
1g	USD 285.00	2 Weeks
5g	USD 650.00	2 Weeks
10g	USD 950.00	2 Weeks

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Related CAS #

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Synonym

Bardos Neu; CGA 169374; CGA-169374; CGA169374; Difenoconazole; Difenconazole; Dragon; Plover; Score

IUPAC/Chemical Name

1-((2-(2-chloro-4-(4-chlorophenoxy)phenyl)-4-methyl-1,3-dioxolan-2-yl)methyl)-1H-1,2,4-triazole

InChi Key

BQYJATMQXGBDHF-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H17Cl2N3O3/c1-13-9-25-19(27-13,10-24-12-22-11-23-24)17-7-6-16(8-18(17)21)26-15-4-2-14(20)3-5-15/h2-8,11-13H,9-10H2,1H3

SMILES Code

CC1OC(CN2N=CN=C2)(C3=CC=C(OC4=CC=C(Cl)C=C4)C=C3Cl)OC1

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 406.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Concentrations and dissipation of difenoconazole and fluxapyroxad residues in apples and soil, determined by ultrahigh-performance liquid chromatography electrospray ionization tandem mass spectrometry. Environ Sci Pollut Res Int. 2016 Mar;23(6):5618-26. doi: 10.1007/s11356-015-5750-6. Epub 2015 Nov 18. PubMed PMID: 26578373. 5: Zhang Z, Jiang W, Jian Q, Song W, Zheng Z, Wang D, Liu X. Residues and dissipation kinetics of triazole fungicides difenoconazole and propiconazole in wheat and soil in Chinese fields. Food Chem. 2015 Feb 1;168:396-403. doi: 10.1016/j.foodchem.2014.07.087. Epub 2014 Jul 24. PubMed PMID: 25172726. 6: Dong F, Li J, Chankvetadze B, Cheng Y, Xu J, Liu X, Li Y, Chen X, Bertucci C, Tedesco D, Zanasi R, Zheng Y. Chiral triazole fungicide difenoconazole: absolute stereochemistry, stereoselective bioactivity, aquatic toxicity, and environmental behavior in vegetables and soil. Environ Sci Technol. 2013 Apr 2;47(7):3386-94. doi: 10.1021/es304982m. Epub 2013 Mar 15. PubMed PMID: 23451708. 7: Leng P, Zhang Z, Li Q, Zhang Y, Zhao M, Pan G. Development of a difenoconazole/propiconazole microemulsion and its antifungal activities against Rhizoctonia solani AG1-IA. Pharmazie. 2012 Jun;67(6):534-41. PubMed PMID: 22822543. 8: Hingmire S, Oulkar DP, Utture SC, Ahammed Shabeer TP, Banerjee K. Residue analysis of fipronil and difenoconazole in okra by liquid chromatography tandem mass spectrometry and their food safety evaluation. Food Chem. 2015 Jun 1;176:145-51. doi: 10.1016/j.foodchem.2014.12.049. Epub 2014 Dec 20. PubMed PMID: 25624217. 9: Mu X, Pang S, Sun X, Gao J, Chen J, Chen X, Li X, Wang C. Evaluation of acute and developmental effects of difenoconazole via multiple stage zebrafish assays. Environ Pollut. 2013 Apr;175:147-57. doi: 10.1016/j.envpol.2012.12.029. Epub 2013 Feb 5. PubMed PMID: 23391686. 10: Wang K, Wu JX, Zhang HY. Dissipation of difenoconazole in rice, paddy soil, and paddy water under field conditions. Ecotoxicol Environ Saf. 2012 Dec;86:111-5. doi: 10.1016/j.ecoenv.2012.08.026. Epub 2012 Oct 10. PubMed PMID: 23062559. 11: Liang X, Yu L, Gui W, Zhu G. Exposure to difenoconazole causes changes of thyroid hormone and gene expression levels in zebrafish larvae. Environ Toxicol Pharmacol. 2015 Nov;40(3):983-7. doi: 10.1016/j.etap.2015.10.005. Epub 2015 Oct 28. PubMed PMID: 26590868. 12: Mu X, Wang K, Chai T, Zhu L, Yang Y, Zhang J, Pang S, Wang C, Li X. Sex specific response in cholesterol level in zebrafish (Danio rerio) after long-term exposure of difenoconazole. Environ Pollut. 2015 Feb;197:278-86. doi: 10.1016/j.envpol.2014.11.019. Epub 2014 Dec 5. PubMed PMID: 25483594. 13: Bhat M, Wani AA, Mukhtar M, Sherwani A, Bhat AH, Showkat A. Dissipation patterns of the fungicide difenoconazole (25% EC) in apples grown in Kashmir, India. Environ Monit Assess. 2015 Jul;187(7):398. doi: 10.1007/s10661-015-4625-0. Epub 2015 Jun 4. PubMed PMID: 26038317. 14: Huan Z, Xu Z, Lv D, Xie D, Luo J. Dissipation and residues of difenoconazole and azoxystrobin in bananas and soil in two agro-climatic zones of China. Bull Environ Contam Toxicol. 2013 Dec;91(6):734-8. doi: 10.1007/s00128-013-1128-y. Epub 2013 Oct 22. PubMed PMID: 24145925. 15: Mu X, Chai T, Wang K, Zhu L, Huang Y, Shen G, Li Y, Li X, Wang C. The developmental effect of difenoconazole on zebrafish embryos: A mechanism research. Environ Pollut. 2016 May;212:18-26. doi: 10.1016/j.envpol.2016.01.035. Epub 2016 Feb 1. PubMed PMID: 26840512. 16: Heleno FF, de Queiroz ME, Neves AA, Freitas RS, Faroni LR, De Oliveira AF. Effects of ozone fumigation treatment on the removal of residual difenoconazole from strawberries and on their quality. J Environ Sci Health B. 2014;49(2):94-101. doi: 10.1080/03601234.2014.846736. PubMed PMID: 24328541. 17: Cho S, Kang G, Lee S, Kim TH. Crystal structure of difenoconazole. 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