Synonym
L-573655; L 573655; L573655; L-573,655; L 573,655; L573,655;
IUPAC/Chemical Name
N-hydroxy-2-phenyl-4,5-dihydro-1,3-oxazole-4-carboxamide
InChi Key
WXOVMEKLQFRMEM-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H10N2O3/c13-9(12-14)8-6-15-10(11-8)7-4-2-1-3-5-7/h1-5,8,14H,6H2,(H,12,13)
SMILES Code
O=C(C1N=C(C2=CC=CC=C2)OC1)NO
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
206.20
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Jackman JE, Fierke CA, Tumey LN, Pirrung M, Uchiyama T, Tahir SH, Hindsgaul O,
Raetz CR. Antibacterial agents that target lipid A biosynthesis in gram-negative
bacteria. Inhibition of diverse
UDP-3-O-(r-3-hydroxymyristoyl)-n-acetylglucosamine deacetylases by substrate
analogs containing zinc binding motifs. J Biol Chem. 2000 Apr 14;275(15):11002-9.
PubMed PMID: 10753902.
2: Chen MH, Steiner MG, de Laszlo SE, Patchett AA, Anderson MS, Hyland SA, Onishi
HR, Silver LL, Raetz CR. Carbohydroxamido-oxazolidines: antibacterial agents that
target lipid A biosynthesis. Bioorg Med Chem Lett. 1999 Feb 8;9(3):313-8. PubMed
PMID: 10091675.
3: Onishi HR, Pelak BA, Gerckens LS, Silver LL, Kahan FM, Chen MH, Patchett AA,
Galloway SM, Hyland SA, Anderson MS, Raetz CR. Antibacterial agents that inhibit
lipid A biosynthesis. Science. 1996 Nov 8;274(5289):980-2. PubMed PMID: 8875939.