MedKoo Cat#: 526128 | Name: LOM612

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LOM612 is a novel Activator of FOXO Nuclear-Cytoplasmic Shuttling, inducing nuclear translocation of a FOXO3a reporter protein as well as endogenous FOXO3a and FOXO1 in U2OS cells in a dose-dependent manner.

Chemical Structure

LOM612
LOM612
CAS#77202-28-9

Theoretical Analysis

MedKoo Cat#: 526128

Name: LOM612

CAS#: 77202-28-9

Chemical Formula: C17H9NO2S

Exact Mass: 291.0354

Molecular Weight: 291.32

Elemental Analysis: C, 70.09; H, 3.11; N, 4.81; O, 10.98; S, 11.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
LOM612
IUPAC/Chemical Name
3-Phenyl-naphtho[2,3-d]isothiazole-4,9-dione
InChi Key
LKMDHRKGPJJYEI-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H9NO2S/c19-15-11-8-4-5-9-12(11)16(20)17-13(15)14(18-21-17)10-6-2-1-3-7-10/h1-9H
SMILES Code
O=C(C1=C2SN=C1C3=CC=CC=C3)C4=C(C=CC=C4)C2=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 291.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cautain B, Castillo F, Musso L, Ferreira BI, de Pedro N, Rodriguez Quesada L, Machado S, Vicente F, Dallavalle S, Link W. Discovery of a Novel, Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic Shuttling. PLoS One. 2016 Dec 9;11(12):e0167491. doi: 10.1371/journal.pone.0167491. eCollection 2016. PubMed PMID: 27936162; PubMed Central PMCID: PMC5147912.