Prilocaine | CAS# 721-50-6 |

MedKoo Cat#: 592999 | Name: Prilocaine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Prilocaine is a local anesthetic that is similar pharmacologically to LIDOCAINE.

Chemical Structure

Prilocaine

CAS# 721-50-6

Theoretical Analysis

MedKoo Cat#: 592999

Name: Prilocaine

CAS#: 721-50-6

Chemical Formula: C13H20N2O

Exact Mass: 220.1576

Molecular Weight: 220.32

Elemental Analysis: C, 70.87; H, 9.15; N, 12.72; O, 7.26

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Prilocaine

IUPAC/Chemical Name

o-Propionotoluidide, 2-(propylamino)-

InChi Key

MVFGUOIZUNYYSO-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H20N2O/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2/h5-8,11,14H,4,9H2,1-3H3,(H,15,16)

SMILES Code

CC(NCCC)C(NC1=CC=CC=C1C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 220.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Blocking ion channels induced by antifungal lipopeptide syringomycin E with amide-linked local anesthetics. Sci Rep. 2018 Aug 1;8(1):11543. doi: 10.1038/s41598-018-30077-6. PubMed PMID: 30069037; PubMed Central PMCID: PMC6070474. 4: Porst H, Burri A. Novel Treatment for Premature Ejaculation in the Light of Currently Used Therapies: A Review. Sex Med Rev. 2018 Jul 26. pii: S2050-0521(18)30058-1. doi: 10.1016/j.sxmr.2018.05.001. [Epub ahead of print] Review. PubMed PMID: 30057136. 5: Porst H, Burri A. Fortacin™ Spray for the Treatment of Premature Ejaculation. Urologia. 2017 Dec;84(2_suppl):1-10. doi: 10.5301/uj.5000275. PubMed PMID: 30047847. 6: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from http://www.ncbi.nlm.nih.gov/books/NBK501610/ PubMed PMID: 30000671. 7: St George G, Morgan A, Meechan J, Moles DR, Needleman I, Ng YL, Petrie A. Injectable local anaesthetic agents for dental anaesthesia. Cochrane Database Syst Rev. 2018 Jul 10;7:CD006487. doi: 10.1002/14651858.CD006487.pub2. Review. PubMed PMID: 29990391. 8: Büttner B, Mansur A, Kalmbach M, Hinz J, Volk T, Szalai K, Roessler M, Bergmann I. Prehospital ultrasound-guided nerve blocks improve reduction-feasibility of dislocated extremity injuries compared to systemic analgesia. A randomized controlled trial. PLoS One. 2018 Jul 2;13(7):e0199776. doi: 10.1371/journal.pone.0199776. eCollection 2018. PubMed PMID: 29965991; PubMed Central PMCID: PMC6028078. 9: Qureshi AI, Saleem MA, Naseem N, Aytac E, Akpinar CK, Wallery SS. Effectiveness of Topical Lidocaine-Prilocaine Cream for Pain Control During Femoral Artery Catheterization in Adult Patients: A Prospective Study. J Vasc Interv Neurol. 2018 Jun;10(1):60-64. PubMed PMID: 29922408; PubMed Central PMCID: PMC5999301. 10: Gupta R, Kaur S, Dahiya P, Kumar M. Comparative evaluation of efficacy of EMLA and needleless jet anesthesia in non-surgical periodontal therapy. J Oral Biol Craniofac Res. 2018 May-Aug;8(2):118-121. doi: 10.1016/j.jobcr.2018.04.001. Epub 2018 Apr 30. PubMed PMID: 29892533; PubMed Central PMCID: PMC5993459. 11: Kesici S, Kesici U, Ulusoy H, Erturkuner P, Turkmen A, Arda O. [Effects of local anesthetics on wound healing]. Rev Bras Anestesiol. 2018 Jul - Aug;68(4):375-382. doi: 10.1016/j.bjan.2018.01.016. Epub 2018 Jun 6. Portuguese. PubMed PMID: 29884529. 12: Grillo DA, Albano JMR, Mocskos EE, Facelli JC, Pickholz M, Ferraro MB. Mechanical properties of drug loaded diblock copolymer bilayers: A molecular dynamics study. J Chem Phys. 2018 Jun 7;148(21):214901. doi: 10.1063/1.5028377. PubMed PMID: 29884038; PubMed Central PMCID: PMC5988549. 13: Wakita R, Fukayama H. Methemoglobinemia should be suspected when oxygen saturation apparently decreases after prilocaine infiltration during intravenous sedation. Clin Case Rep. 2018 Apr 17;6(6):1077-1081. doi: 10.1002/ccr3.1522. eCollection 2018 Jun. PubMed PMID: 29881568; PubMed Central PMCID: PMC5986061. 14: Bragagni M, Gil-Alegre ME, Mura P, Cirri M, Ghelardini C, Di Cesare Mannelli L. Improving the therapeutic efficacy of prilocaine by PLGA microparticles: Preparation, characterization and in vivo evaluation. Int J Pharm. 2018 Aug 25;547(1-2):24-30. doi: 10.1016/j.ijpharm.2018.05.054. Epub 2018 May 23. PubMed PMID: 29800738. 15: Perez-Lopez FR, Martinez-Dominguez SJ, Perez-Roncero GR, Hernandez AV. Uterine or paracervical lidocaine application for pain control during intrauterine contraceptive device insertion: a meta-analysis of randomised controlled trials. Eur J Contracept Reprod Health Care. 2018 Jun;23(3):207-217. doi: 10.1080/13625187.2018.1469124. Epub 2018 May 24. PubMed PMID: 29792756. 16: Caré W, Larabi IA, Langrand J, Medernach C, Alvarez JC, Villa A. Poisoning associated with inappropriate use of a eutectic mixture of lidocaine and prilocaine before laser-assisted hair removal: about 3 cases. Int J Legal Med. 2018 May 21. doi: 10.1007/s00414-018-1858-9. [Epub ahead of print] PubMed PMID: 29785585. 17: Gebhardt V, Kiefer K, Bussen D, Weiss C, Schmittner MD. Retrospective analysis of mepivacaine, prilocaine and chloroprocaine for low-dose spinal anaesthesia in outpatient perianal procedures. Int J Colorectal Dis. 2018 May 13. doi: 10.1007/s00384-018-3085-8. [Epub ahead of print] PubMed PMID: 29756162. 18: Qureshi AA, Friedman AJ. Complex Regional Pain Syndrome: What the Dermatologist Should Know. J Drugs Dermatol. 2018 May 1;17(5):532-536. PubMed PMID: 29742184. 19: Dernek B, Adiyeke L, Duymus TM, Gokcedag A, Kesiktas FN, Aksoy C. Efficacy of Trigger Point Injections in Patients with Lumbar Disc Hernia without Indication for Surgery. Asian Spine J. 2018 Apr;12(2):232-237. doi: 10.4184/asj.2018.12.2.232. Epub 2018 Apr 16. PubMed PMID: 29713403; PubMed Central PMCID: PMC5913013. 20: Khongkhunthian S, Sastraruji T, Klayraung S, Okonogi S. Efficacy of anesthetic rice nanogel on pain reduction in human oral cavity. Drug Discov Ther. 2018;12(1):31-36. doi: 10.5582/ddt.2018.01003. PubMed PMID: 29553081.