Closantel sodium | CAS#61438-64-0 | protonophore | chitinase OvCHT1 inhibitor

MedKoo Cat#: 540086 | Name: Closantel sodium

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Closantel sodium is a protonophore and chitinase OvCHT1 inhibitor that inhibits nematode development and parasite survival.

Chemical Structure

Closantel sodium

CAS#61438-64-0 (sodium)

Theoretical Analysis

MedKoo Cat#: 540086

Name: Closantel sodium

CAS#: 61438-64-0 (sodium)

Chemical Formula: C22H13Cl2I2N2NaO2

Exact Mass: 683.8341

Molecular Weight: 685.05

Elemental Analysis: C, 38.57; H, 1.91; Cl, 10.35; I, 37.05; N, 4.09; Na, 3.36; O, 4.67

Price and Availability

Size	Price	Availability
5g	USD 350.00	2 Weeks
10g	USD 550.00	2 Weeks
25g	USD 950.00	2 Weeks

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Related CAS #

57808-65-8 (free) 61438-64-0 (sodium)

Synonym

Closantel sodium; KM-0510; KM0510; KM 0510; KS-1256; KS1256; KS 1256;

IUPAC/Chemical Name

sodium 2-((5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)carbamoyl)-4,6-diiodophenolate

InChi Key

LREGMDNUOGTSIK-UHFFFAOYSA-M

InChi Code

InChI=1S/C22H14Cl2I2N2O2.Na/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29;/h2-9,17,29H,1H3,(H,28,30);/q;+1/p-1

SMILES Code

[O-]C1=C(I)C=C(I)C=C1C(NC2=CC(Cl)=C(C(C3=CC=C(Cl)C=C3)C#N)C=C2C)=O.[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 685.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Yuan W, Liu JM, Lu K, Li H, Duan MM, Feng JT, Hong Y, Liu YP, Zhou Y, Tong LB, Lu J, Zhu CG, Jin YM, Cheng GF, Lin JJ. Molecular identification and seasonal infections of species of Fasciola in ruminants from two provinces in China. J Helminthol. 2016 May;90(3):359-63. doi: 10.1017/S0022149X15000383. Epub 2015 Jun 30. PubMed PMID: 26123576. 2: De Brabander M, Geuens G, Nuydens R, Willebrords R, De Mey J. Microtubule stability and assembly in living cells: the influence of metabolic inhibitors, taxol and pH. Cold Spring Harb Symp Quant Biol. 1982;46 Pt 1:227-40. PubMed PMID: 6125293. 3: Kikuchi E, Mori T, Zeniya M, Isobe K, Ishigami-Yuasa M, Fujii S, Kagechika H, Ishihara T, Mizushima T, Sasaki S, Sohara E, Rai T, Uchida S. Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters. J Am Soc Nephrol. 2015 Jul;26(7):1525-36. doi: 10.1681/ASN.2014060560. Epub 2014 Nov 5. PubMed PMID: 25377078; PubMed Central PMCID: PMC4483590. 4: Louw JP, Reinecke RK. Overberg research projects. XV. The efficacy of different anthelmintics against field strains of nematode parasites of sheep in the southern Cape Province. J S Afr Vet Assoc. 1993 Jun;64(2):71-5. PubMed PMID: 8410946. 5: Abdel-Aziz O, Hussien EM, El Kosasy AM, Ahmed N. Comparative Study of Univariate Spectrophotometry and Multivariate Calibration for the Determination of Levamisole Hydrochloride and Closantel Sodium in a Binary Mixture. J AOAC Int. 2016 Jul;99(4):941-7. doi: 10.5740/jaoacint.15-0252. Epub 2016 Jun 4. PubMed PMID: 27302698. 6: Heredia R, Aguilar E, Romero C, Bautista L, Mendoza G. Evaluation of five treatments to control intestinal parasites in sheep in Ayapango, state of Mexico. Vet World. 2016 Nov;9(11):1233-1237. Epub 2016 Nov 12. PubMed PMID: 27956774; PubMed Central PMCID: PMC5146303. 7: Fleischer R, Heermann R, Jung K, Hunke S. Purification, reconstitution, and characterization of the CpxRAP envelope stress system of Escherichia coli. J Biol Chem. 2007 Mar 23;282(12):8583-93. Epub 2007 Jan 26. PubMed PMID: 17259177.

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Clothianidin