Selvigaltin, also known as GB0139, is a galectin-3 inhibitor. GB0139 protects against acute lung injury by inhibiting neutrophil recruitment and activation. B0139 decreased inflammation severity via a reduction in neutrophil and macrophage recruitment and neutrophil activation. GB0139 reduced LPS-mediated increases in interleukin (IL)-6, tumor necrosis factor alpha (TNFα) and macrophage inflammatory protein-1-alpha. In vitro, GB0139 inhibited Gal-3-induced neutrophil activation, monocyte IL-8 secretion, T cell apoptosis and the upregulation of pro-inflammatory genes encoding for IL-8, TNFα, IL-6 in alveolar epithelial cells in response to mechanical stretch.
MedKoo Cat#: 121095
Name: Selvigaltin
CAS#: 1978336-95-6
Chemical Formula: C19H16BrF3N4O4S
Exact Mass: 532.0028
Molecular Weight: 533.32
Elemental Analysis: C, 42.79; H, 3.02; Br, 14.98; F, 10.69; N, 10.51; O, 12.00; S, 6.01
The following data is based on the product molecular weight 533.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
