MedKoo Cat#: 526059 | Name: PKUMDL-WQ-2101
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

PKUMDL-WQ-2101 is a novel selective allosteric inhibitor of PHGDH and serine synthesis with anti-tumor activity, binding to site I.

Chemical Structure

PKUMDL-WQ-2101
PKUMDL-WQ-2101
CAS#304481-72-9

Theoretical Analysis

MedKoo Cat#: 526059

Name: PKUMDL-WQ-2101

CAS#: 304481-72-9

Chemical Formula: C14H11N3O6

Exact Mass: 317.0648

Molecular Weight: 317.26

Elemental Analysis: C, 53.00; H, 3.49; N, 13.25; O, 30.26

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
1g USD 3,950.00 2 Weeks
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Related CAS #
304481-72-9;
Synonym
PKUMDL-WQ-2101; PKUMDL-WQ2101; PKUMDL-WQ 2101; WQ 2101; WQ2101; WQ-2101;
IUPAC/Chemical Name
(E)-2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide
InChi Key
OXONIXZPWKJHMW-VIZOYTHASA-N
InChi Code
InChI=1S/C14H11N3O6/c18-10-2-3-11(13(20)6-10)14(21)16-15-7-8-5-9(17(22)23)1-4-12(8)19/h1-7,18-20H,(H,16,21)/b15-7+
SMILES Code
O=C(N/N=C/C1=CC([N+]([O-])=O)=CC=C1O)C2=CC=C(O)C=C2O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 317.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Soflaee MH, Kesavan R, Sahu U, Tasdogan A, Villa E, Djabari Z, Cai F, Tran DH, Vu HS, Ali ES, Rion H, O'Hara BP, Kelekar S, Hallett JH, Martin M, Mathews TP, Gao P, Asara JM, Manning BD, Ben-Sahra I, Hoxhaj G. Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway. Nat Commun. 2022 May 16;13(1):2698. doi: 10.1038/s41467-022-30362-z. PMID: 35577785; PMCID: PMC9110385.