MedKoo Cat#: 526047 | Name: NSC16168
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NSC16168 is a specific inhibitor of ERCC1-XPF with no effect on both HhaI and XPG.

Chemical Structure

NSC16168
NSC16168
CAS#6837-93-0

Theoretical Analysis

MedKoo Cat#: 526047

Name: NSC16168

CAS#: 6837-93-0

Chemical Formula: C17H15NO9S3

Exact Mass: 472.9909

Molecular Weight: 473.49

Elemental Analysis: C, 43.12; H, 3.19; N, 2.96; O, 30.41; S, 20.31

Price and Availability

Size Price Availability Quantity
5mg USD 500.00 2 Weeks
25mg USD 950.00 2 Weeks
100mg USD 2,050.00 2 Weeks
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Related CAS #
No Data
Synonym
NSC16168
IUPAC/Chemical Name
4-Amino-5-(4-methylphenyl)sulfonyloxynaphthalene-2,7-disulfonic acid
InChi Key
ZIQWUYNDHGXLIN-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H15NO9S3/c1-10-2-4-12(5-3-10)30(25,26)27-16-9-14(29(22,23)24)7-11-6-13(28(19,20)21)8-15(18)17(11)16/h2-9H,18H2,1H3,(H,19,20,21)(H,22,23,24)
SMILES Code
O=S(C1=CC(N)=C2C(OS(=O)(C3=CC=C(C)C=C3)=O)=CC(S(=O)(O)=O)=CC2=C1)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 473.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Arora S, Heyza J, Zhang H, Kalman-Maltese V, Tillison K, Floyd AM, Chalfin EM, Bepler G, Patrick SM. Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells. Oncotarget. 2016 Nov 15;7(46):75104-75117. doi: 10.18632/oncotarget.12072. PubMed PMID: 27650543; PubMed Central PMCID: PMC5342726.