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MedKoo Cat#: 540079 | Name: Clindamycin Palmitate HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clindamycin Palmitate HCl a ribosomal translocation and protein synthesis inhibitor that displays efficacy against MRSA. It is also occasionally used to treat Plasmodium.

Chemical Structure

Clindamycin Palmitate HCl
Clindamycin Palmitate HCl
CAS#25507-04-4 (palmitate HCl)

Theoretical Analysis

MedKoo Cat#: 540079

Name: Clindamycin Palmitate HCl

CAS#: 25507-04-4 (palmitate HCl)

Chemical Formula: C34H64Cl2N2O6S

Exact Mass: 0.0000

Molecular Weight: 699.85

Elemental Analysis: C, 58.35; H, 9.22; Cl, 10.13; N, 4.00; O, 13.72; S, 4.58

Price and Availability

Size Price Availability Quantity
50mg USD 350.00 2 Weeks
100mg USD 650.00 2 Weeks
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Related CAS #
25507-04-4 (palmitate HCl) 21462-39-5 (HCl) 18323-44-9 (free) 24729-96-2 (phosphate) 58207-19-5 (HCl monohydrate)
Synonym
Cleocin pediatric; Clindamycin 2-Palmitate hydrochloride; U 25179E; U-25179-E; U25179E
IUPAC/Chemical Name
(2R,3R,4S,5R,6R)-6-((1S,2S)-2-chloro-1-((2S,4R)-1-methyl-4-propylpyrrolidine-2-carboxamido)propyl)-4,5-dihydroxy-2-(methylthio)tetrahydro-2H-pyran-3-yl palmitate hydrochloride
InChi Key
GTNDZRUWKHDICY-DJHAJVGHSA-N
InChi Code
InChI=1S/C34H63ClN2O6S.ClH/c1-6-8-9-10-11-12-13-14-15-16-17-18-19-21-27(38)42-32-30(40)29(39)31(43-34(32)44-5)28(24(3)35)36-33(41)26-22-25(20-7-2)23-37(26)4;/h24-26,28-32,34,39-40H,6-23H2,1-5H3,(H,36,41);1H/t24-,25+,26-,28+,29+,30-,31+,32+,34+;/m0./s1
SMILES Code
CCCCCCCCCCCCCCCC(O[C@@H]1[C@H]([C@H]([C@@H]([C@@H]([C@@H](Cl)C)NC([C@@H]2C[C@H](CN2C)CCC)=O)O[C@@H]1SC)O)O)=O.Cl
Appearance
White to off-white solid powder.
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 699.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bharathi Ch, Jayaram P, Sunder Raj J, Saravana Kumar M, Bhargavi V, Handa VK, Dandala R, Naidu A. Identification, isolation and characterization of impurities of clindamycin palmitate hydrochloride. J Pharm Biomed Anal. 2008 Dec 1;48(4):1211-8. doi: 10.1016/j.jpba.2008.08.011. Epub 2008 Aug 20. PubMed PMID: 18947955. 2: Stillerman M, Isenberg HD, Facklam RR. Streptococcal pharyngitis therapy: comparison of clindamycin palmitate and potassium phenoxymethyl penicillin. Antimicrob Agents Chemother. 1973 Nov;4(5):514-20. PubMed PMID: 4208902; PubMed Central PMCID: PMC444587. 3: Brown LW. High-pressure liquid chromatographic assays for clindamycin, clindamycin phosphate, and clindamycin palmitate. J Pharm Sci. 1978 Sep;67(9):1254-7. PubMed PMID: 690831. 4: De Haan RM, Vanden Bosch WD, Metzler CM. Clindamycin serum concentrations after administration of clindamycin palmitate with food. J Clin Pharmacol New Drugs. 1972 May-Jun;12(5):205-11. PubMed PMID: 4555880. 5: Ruoff G, Panzer JD, Atkinson WH. The serumcidality of clindamycin palmitate. Mich Med. 1973 Sep;72(27):625-6. PubMed PMID: 4743615. 6: De Haan RM, Schellenberg D, Vanden Bosch WD, Maile MH. Clindamycin palmitate in healthy men: general tolerance and effect on stools. Curr Ther Res Clin Exp. 1972 Feb;14(2):81-90. PubMed PMID: 4622442. 7: Campbell IW, Hossack DJ, Munro JF. Absorption and urinary excretion of clindamycin palmitate in the elderly. Curr Med Res Opin. 1973;1(6):369-75. PubMed PMID: 4772325. 8: Mikuni M, Oishi M, Imai M, Takahashi T, Tanaka M. [Ophthalmic use of clindamycin palmitate (author's transl)]. Jpn J Antibiot. 1973 Aug;26(4):409-14. Japanese. PubMed PMID: 4542679. 9: DeHaan RM, Schellenberg D. Clindamycin palmitate flavored granules. Multidose tolerance, absorption, and urinary excretion study in healthy children. J Clin Pharmacol New Drugs. 1972 Feb-Mar;12(2):74-83. PubMed PMID: 4480976. 10: Rowe EL, Machkovech SM. Rapid acetylation of a dihydroxy compound by 4-(dimethylamino)pyridine catalysis: application to GLC determination of clindamycin palmitate hydrochloride. J Pharm Sci. 1977 Feb;66(2):273-5. PubMed PMID: 839429. 11: Carr WG. Clindamycin palmitate hydrochloride: a clinical trial in a pediatric office practice. Curr Ther Res Clin Exp. 1973 Sep;15(9):630-40. PubMed PMID: 4201546. 12: Tokuda H, Hatano H, Kayaba T. [Use of clindamycin palmitate in ophthalmology (author's transl)]. Jpn J Antibiot. 1973 Aug;26(4):404-8. Japanese. PubMed PMID: 4542678. 13: Iwasawa T. [Basic and clinical evaluation on clindamycin palmitate in otorhinolaryngological field infection (author's transl)]. Jpn J Antibiot. 1973 Aug;26(4):393-9. Japanese. PubMed PMID: 4542676. 14: Randolph MF, Redys JJ, Cope J, Morris KE. Streptococcal pharyngitis: posttreatment carrier prevalence and clinical relapse in children treated with clindamycin palmitate or phenoxymethyl penicillin. Clin Pediatr (Phila). 1975 Feb;14(2):119-22. PubMed PMID: 803421. 15: Hirota WK, Wortmann GW, Maydonovitch CL, Chang AS, Midkiff RB, Wong RK, Moses FM. The effect of oral decontamination with clindamycin palmitate on the incidence of bacteremia after esophageal dilation: a prospective trial. Gastrointest Endosc. 1999 Oct;50(4):475-9. PubMed PMID: 10502166. 16: Rodriguez W, Ross S, Khan W, McKay D, Moskowitz P. Clindamycin in the treatment of osteomyelitis in children: a report of 29 cases. Am J Dis Child. 1977 Oct;131(10):1088-93. PubMed PMID: 910760. 17: Cimbollek M, Nies B, Wenz R, Kreuter J. Antibiotic-impregnated heart valve sewing rings for treatment and prophylaxis of bacterial endocarditis. Antimicrob Agents Chemother. 1996 Jun;40(6):1432-7. PubMed PMID: 8726015; PubMed Central PMCID: PMC163345. 18: Pastori A, Neri E, Viviano G. [Clinical evaluation of 7-chlorolincomycin palmitate]. Minerva Pediatr. 1979 Sep 15;31(17):1305-8. Italian. PubMed PMID: 537598. 19: Leigh DA. Antibacterial activity and pharmacokinetics of clindamycin. J Antimicrob Chemother. 1981 Jun;7 Suppl A:3-9. Review. PubMed PMID: 7019193. 20: Song P, Li W, Zhou Q. An outpatient antibacterial stewardship intervention during the journey to JCI accreditation. BMC Pharmacol Toxicol. 2014 Feb 26;15:8. doi: 10.1186/2050-6511-15-8. PubMed PMID: 24568120; PubMed Central PMCID: PMC3937530.