ZK216348 | CAS#669073-68-1 Glucocorticoid Receptor (GR) Agonist

MedKoo Cat#: 533003 | Name: ZK216348

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ZK216348 is a selective nonsteroidal glucocorticoid receptor (GR) agonist for the treatment of experimental colitis with IC50 values of 20, 20, and 80 nM for GR, Progesterone (PR) and Mineralocorticoid (MR) receptors respectively. (ZK 216348 shows anti-inflammatory activity comparable to prednisolone for both systemic and topical application.

Chemical Structure

ZK216348

CAS#669073-68-1

Theoretical Analysis

MedKoo Cat#: 533003

Name: ZK216348

CAS#: 669073-68-1

Chemical Formula: C24H23F3N2O5

Exact Mass: 476.1559

Molecular Weight: 476.45

Elemental Analysis: C, 60.50; H, 4.87; F, 11.96; N, 5.88; O, 16.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

ZK216348; ZK 216348; ZK-216348.

IUPAC/Chemical Name

4-(2,3-dihydro-1-benzofuran-7-yl)-2-hydroxy-4-methyl-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)-2-(trifluoromethyl)pentanamide

InChi Key

VRZVKIJRJRBQJT-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H23F3N2O5/c1-13-17-11-15(7-8-16(17)20(30)34-29-13)28-21(31)23(32,24(25,26)27)12-22(2,3)18-6-4-5-14-9-10-33-19(14)18/h4-8,11,32H,9-10,12H2,1-3H3,(H,28,31)

SMILES Code

CC(C)(C1=CC=CC2=C1OCC2)CC(C(F)(F)F)(O)C(NC3=CC=C(C(ON=C4C)=O)C4=C3)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 476.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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