Autophinib | CAS#1644443-47-9 | VPS34 inhibitor

MedKoo Cat#: 525896 | Name: Autophinib

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Autophinib is a small molecule inhibitor designed to target and modulate the process of autophagy, particularly by inhibiting specific autophagy-related proteins. It has shown potential in preclinical studies for its ability to suppress cancer cell growth by interfering with the autophagic flux that cancer cells often rely on for survival under stress conditions. By targeting the autophagic pathway, Autophinib may enhance the effectiveness of other anticancer therapies and reduce tumor progression.

Chemical Structure

Autophinib

CAS#1644443-47-9

Theoretical Analysis

MedKoo Cat#: 525896

Name: Autophinib

CAS#: 1644443-47-9

Chemical Formula: C14H11ClN6O3

Exact Mass: 346.0581

Molecular Weight: 346.73

Elemental Analysis: C, 48.50; H, 3.20; Cl, 10.22; N, 24.24; O, 13.84

Price and Availability

Size	Price	Availability
10mg	USD 110.00	Ready to ship
25mg	USD 190.00	Ready to ship
50mg	USD 350.00	Ready to ship
100mg	USD 550.00	Ready to ship
200mg	USD 850.00	Ready to ship
500mg	USD 1,450.00	Ready to ship
1g	USD 2,750.00	Ready to ship

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Related CAS #

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Synonym

Autophinib

IUPAC/Chemical Name

6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)pyrimidin-4-amine

InChi Key

CEUMAXLRGBKFQP-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H11ClN6O3/c1-8-6-13(20-19-8)17-12-7-11(15)16-14(18-12)24-10-4-2-9(3-5-10)21(22)23/h2-7H,1H3,(H2,16,17,18,19,20)

SMILES Code

O=[N+](C1=CC=C(OC2=NC(Cl)=CC(NC3=NNC(C)=C3)=N2)C=C1)[O-]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Certificate of Analysis

View CoA: current batch, Lot#A8T12K09

QC Data

View QC data: current batch, Lot#A8T12K09

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	DMSO	14.0	40.32

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 346.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Yang Y, Chen D, Liu H, Yang K. Increased expression of lncRNA CASC9 promotes tumor progression by suppressing autophagy-mediated cell apoptosis via the AKT/mTOR pathway in oral squamous cell carcinoma. Cell Death Dis. 2019 Jan 17;10(2):41. doi: 10.1038/s41419-018-1280-8. PMID: 30674868; PMCID: PMC6381212. 2: Robke L, Laraia L, Carnero Corrales MA, Konstantinidis G, Muroi M, Richters A, Winzker M, Engbring T, Tomassi S, Watanabe N, Osada H, Rauh D, Waldmann H, Wu YW, Engel J. Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34. Angew Chem Int Ed Engl. 2017 Jul 3;56(28):8153-8157. doi: 10.1002/anie.201703738. Epub 2017 Jun 12. PMID: 28544137. 3: Li H, Li M, Chen K, Li Y, Yang Z, Zhou Z. The circadian clock gene ARNTL overexpression suppresses oral cancer progression by inducing apoptosis via activating autophagy. Med Oncol. 2022 Sep 30;39(12):244. doi: 10.1007/s12032-022-01832-7. PMID: 36180647. 4: Duan J, Chen H, Xu D, Li Y, Li X, Cheng J, Hua R, Zhang Z, Yang L, Li Q. 17β-estradiol improves the developmental ability, inhibits reactive oxygen species levels and apoptosis of porcine oocytes by regulating autophagy events. J Steroid Biochem Mol Biol. 2021 May;209:105826. doi: 10.1016/j.jsbmb.2021.105826. Epub 2021 Feb 10. PMID: 33581253. 5: Aleksandrova KV, Suvorova II. Evaluation of the Effectiveness of Various Autophagy Inhibitors in A549 Cancer Stem Cells. Acta Naturae. 2023 Jan- Mar;15(1):19-25. doi: 10.32607/actanaturae.11891. PMID: 37153502; PMCID: PMC10154774. 6: Li Y, Li J, Wei SS, Du J. Lipopolysaccharide-induced Trigeminal Ganglion Nerve Fiber Damage is Associated with Autophagy Inhibition. Curr Med Sci. 2023 Jun;43(3):489-495. doi: 10.1007/s11596-023-2739-0. Epub 2023 Jun 6. PMID: 37278832. 7: Duan J, Chen H, Li Y, Xu D, Li X, Zhang Z, Cheng J, Yang L, Li Q. 17β-Estradiol Enhances Porcine Meiosis Resumption from Autophagy-Induced Gap Junction Intercellular Communications and Connexin 43 Phosphorylation via the MEK/ERK Signaling Pathway. J Agric Food Chem. 2021 Oct 13;69(40):11847-11855. doi: 10.1021/acs.jafc.1c04212. Epub 2021 Oct 5. PMID: 34609142. 8: Hanelova K, Raudenska M, Kratochvilova M, Navratil J, Vicar T, Bugajova M, Gumulec J, Masarik M, Balvan J. Autophagy modulators influence the content of important signalling molecules in PS-positive extracellular vesicles. Cell Commun Signal. 2023 May 24;21(1):120. doi: 10.1186/s12964-023-01126-z. PMID: 37226246; PMCID: PMC10210466. 9: Relic B, Deroyer C, Malaise O, Plener Z, Gillet P, de Seny D, Malaise MG. TFEB phosphorylation on Serine 211 is induced by autophagy in human synovial fibroblasts and by p62/SQSTM1 overexpression in HEK293 cells. Biochem J. 2021 Aug 27;478(16):3145-3155. doi: 10.1042/BCJ20210174. PMID: 34405859; PMCID: PMC8421036. 10: Liu H, Gong X, Yang K. Overexpression of the clock gene Per2 suppresses oral squamous cell carcinoma progression by activating autophagy via the PI3K/AKT/mTOR pathway. J Cancer. 2020 Mar 26;11(12):3655-3666. doi: 10.7150/jca.42771. PMID: 32284762; PMCID: PMC7150464. 11: Yang G, Yang Y, Tang H, Yang K. Loss of the clock gene Per1 promotes oral squamous cell carcinoma progression via the AKT/mTOR pathway. Cancer Sci. 2020 May;111(5):1542-1554. doi: 10.1111/cas.14362. Epub 2020 Mar 18. PMID: 32086839; PMCID: PMC7226219.