Synonym
Flupentixol decanoate, (Z)-; (Z)-flupentixol decanoate; Flupentixol decanoate;
IUPAC/Chemical Name
Decanoic acid, 2-(4-((3Z)-3-(2-(trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)-1-piperazinyl)ethyl ester
InChi Key
UIKWDDSLMBHIFT-WKIKZPBSSA-N
InChi Code
InChI=1S/C33H43F3N2O2S/c1-2-3-4-5-6-7-8-15-32(39)40-24-23-38-21-19-37(20-22-38)18-11-13-27-28-12-9-10-14-30(28)41-31-17-16-26(25-29(27)31)33(34,35)36/h9-10,12-14,16-17,25H,2-8,11,15,18-24H2,1H3/b27-13-
SMILES Code
CCCCCCCCCC(OCCN1CCN(CC/C=C2C3=C(SC4=C\2C=CC=C4)C=CC(C(F)(F)F)=C3)CC1)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
588.77
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Ikeda H, Akiyama G, Fujii Y, Minowa R, Koshikawa N, Cools AR. Role of AMPA and NMDA receptors in the nucleus accumbens shell in turning behaviour of rats: interaction with dopamine receptors. Neuropharmacology. 2003 Jan;44(1):81-7. PubMed PMID: 12559124.
2: Kistrup K, Gerlach J, Aaes-Jørgensen T, Larsen NE. Perphenazine decanoate and cis(z)-flupentixol decanoate in maintenance treatment of schizophrenic outpatients. Serum levels at the minimum effective dose. Psychopharmacology (Berl). 1991;105(1):42-8. PubMed PMID: 1745710.
3: Farde L, Halldin C, Stone-Elander S, Sedvall G. PET analysis of human dopamine receptor subtypes using 11C-SCH 23390 and 11C-raclopride. Psychopharmacology (Berl). 1987;92(3):278-84. PubMed PMID: 2957716.
4: Saikia JK, Jørgensen A. Steady-state serum concentrations after cis (Z)-flupentixol decanoate in viscoleo. Psychopharmacology (Berl). 1983;80(4):371-3. PubMed PMID: 6414008.
5: Jørgensen A, Andersen J, Bjørndal N, Dencker SJ, Lundin L, Malm U. Serum concentrations of cis(Z)-flupentixol and prolactin in chronic schizophrenic patients treated with flupentixol and cis(Z)-flupentixol decanoate. Psychopharmacology (Berl). 1982;77(1):58-65. PubMed PMID: 6812119.
6: Jørgensen A. Pharmacokinetic studies in volunteers of intravenous and oral cis (Z)-flupentixol and intramuscular cis (Z)-flupentixol decanoate in Viscoleo. Eur J Clin Pharmacol. 1980 Oct;18(4):355-60. PubMed PMID: 7439258.
7: Kirk L, Jørgensen A. Concentrations of Cis(Z)-flupentixol in maternal serum, amniotic fluid, umbilical cord serum, and milk. Psychopharmacology (Berl). 1980;72(1):107-8. PubMed PMID: 6781000.
8: Stauning JA, Kirk L, Jøorgensen A. Comparison of serum levels after intramuscular injections of 2% and 10% cis(Z)-flupentixol decanoate in Viscoleo to schizophrenic patients. Psychopharmacology (Berl). 1979 Sep;65(1):69-72. PubMed PMID: 116292.
-flupentixol decanoate4737.jpg "(Z)-flupentixol decanoate")
