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MedKoo Cat#: 540061 | Name: Carbidopa hydrate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Carbidopa is an L-amino acid decarboxylase inhibitor. It inhibits formation of dopamine granules and inhibits restoration of norepinephrine and other catecholamine production in models with mutant isoforms of dopamine β-hydroxylase.

Chemical Structure

Carbidopa hydrate
Carbidopa hydrate
CAS#38821-49-7 (hydrate)

Theoretical Analysis

MedKoo Cat#: 540061

Name: Carbidopa hydrate

CAS#: 38821-49-7 (hydrate)

Chemical Formula: C10H16N2O5

Exact Mass: 0.0000

Molecular Weight: 244.24

Elemental Analysis: C, 49.18; H, 6.60; N, 11.47; O, 32.75

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 Weeks
2g USD 350.00 2 Weeks
5g USD 550.00 2 Weeks
10g USD 850.00 2 Weeks
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Related CAS #
38821-49-7 (hydrate) 28860-95-9 (anhydrous) 65132-60-7 (HCl)
Synonym
Carbidopa; Carbidopa hydrate; Lodosyn; (S)-(-)-Carbidopa monohydrate
IUPAC/Chemical Name
(S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropionic Acid Monohydrate
InChi Key
QTAOMKOIBXZKND-PPHPATTJSA-N
InChi Code
InChI=1S/C10H14N2O4.H2O/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;/h2-4,12-14H,5,11H2,1H3,(H,15,16);1H2/t10-;/m0./s1
SMILES Code
O=C(O)[C@@](C)(NN)CC1=CC=C(O)C(O)=C1.[H]O[H]
Appearance
Solid powder
Purity
>97% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 244.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Polonini HC, Silva SL, Cunha CN, Brandão MA, Ferreira AO. Compatibility of cholecalciferol, haloperidol, imipramine hydrochloride, levodopa/carbidopa, lorazepam, minocycline hydrochloride, tacrolimus monohydrate, terbinafine, tramadol hydrochloride and valsartan in SyrSpend SF PH4 oral suspensions. Pharmazie. 2016 Apr;71(4):185-91. PubMed PMID: 27209697. 2: Vickers S, Stuart EK, Hucker HB. Further studies on the metabolism of carbidopa, (minus)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid monohydrate, in the human, Rhesus monkey, dog, and rat. J Med Chem. 1975 Feb;18(2):134-8. PubMed PMID: 804550. 3: Vickers S, Stuart EK, Bianchine JR, Hucker HB, Jaffe ME, Rhodes RE, Vandenheuvel WJ. Metabolism of carbidopa (1-(-)-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate), an aromatic amino acid decarboxylase inhibitor, in the rat, rhesus monkey, and man. Drug Metab Dispos. 1974 Jan-Feb;2(1):9-22. PubMed PMID: 4150141. 4: Scriabine A, Ludden CT, Stone CA, Wurtman RJ, Watkins CJ. Enhancement of the anti-hypertensive effect of methyldopa and other anti-hypertensive drugs by carbidopa in spontaneously hypertensive rats. Clin Sci Mol Med Suppl. 1976 Dec;3:407s-410s. PubMed PMID: 1071655. 5: Fraenkel G, Blechl A, Blechl J, Herman P, Seligman MI. 3':5'-cyclic AMP and hormonal control of puparium formation in the fleshfly Sarcophaga bullata. Proc Natl Acad Sci U S A. 1977 May;74(5):2182-6. PubMed PMID: 194250; PubMed Central PMCID: PMC431100. 6: Bayes M, Rabasseda X, Prous JR. Gateways to Clinical Trials. June 2002. Methods Find Exp Clin Pharmacol. 2002 Jun;24(5):291-327. Review. PubMed PMID: 12168506. 7: Itskovitz HD, Chen YH, Stier CT Jr. Reciprocal renal effects of dopamine and 5-hydroxytryptamine formed within the rat kidney. Clin Sci (Lond). 1988 Nov;75(5):503-7. PubMed PMID: 3151164. 8: Smith SA, Pogson CL. Tryptophan and the control of plasma glucose concentrations in the rat. Biochem J. 1977 Dec 15;168(3):495-506. PubMed PMID: 147076; PubMed Central PMCID: PMC1183797.

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