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MedKoo Cat#: 461153 | Name: Ranatensin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ranatensin is a undecapeptide isolated from skin of Rana pipiens. It is a naturally occurring bombesin-like peptide.

Chemical Structure

Ranatensin
Ranatensin
CAS#29451-71-6

Theoretical Analysis

MedKoo Cat#: 461153

Name: Ranatensin

CAS#: 29451-71-6

Chemical Formula: C61H84N16O13S

Exact Mass: 1280.6124

Molecular Weight: 1281.50

Elemental Analysis: C, 57.17; H, 6.61; N, 17.49; O, 16.23; S, 2.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ranatensin;
IUPAC/Chemical Name
(S)-N1-((S)-1-(((S)-1-(((S)-1-((2-(((S)-1-(((S)-1-(((S)-1-amino-4-(methylthio)-1-oxobutan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl)amino)-2-oxoethyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-1-oxopropan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-2-((S)-1-(((R)-5-oxopyrrolidine-2-carbonyl)-D-valyl)pyrrolidine-2-carboxamido)pentanediamide
InChi Key
AUOCWSNQHWTPIJ-CFWJHKRRSA-N
InChi Code
1S/C61H84N16O13S/c1-32(2)50(60(89)66-30-49(80)70-45(27-37-29-64-31-67-37)58(87)73-43(25-35-13-8-7-9-14-35)57(86)71-40(52(63)81)22-24-91-6)75-53(82)34(5)68-56(85)44(26-36-28-65-39-16-11-10-15-38(36)39)74-54(83)42(18-20-47(62)78)72-59(88)46-17-12-23-77(46)61(90)51(33(3)4)76-55(84)41-19-21-48(79)69-41/h7-11,13-16,28-29,31-34,40-46,50-51,65H,12,17-27,30H2,1-6H3,(H2,62,78)(H2,63,81)(H,64,67)(H,66,89)(H,68,85)(H,69,79)(H,70,80)(H,71,86)(H,72,88)(H,73,87)(H,74,83)(H,75,82)(H,76,84)/t34-,40-,41?,42-,43-,44-,45-,46-,50?,51?/m0/s1
SMILES Code
O=C([C@H](C(C)C)NC([C@H](C)NC([C@H](Cc(c[nH]1)c2c1cccc2)NC([C@@H](NC([C@H]3N(C([C@H](NC([C@@H]4NC(CC4)=O)=O)C(C)C)=O)CCC3)=O)CCC(N)=O)=O)=O)=O)NCC(N[C@@H](Cc5cnc[nH]5)C(N[C@H](C(N[C@H](C(N)=O)CCSC)=O)Cc6ccccc6)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,281.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Geller RG, Govier WC, Pisano JJ, Tanimura T, Van Clineschmidt B. The action of ranatensin, a new polypeptide from amphibian skin, on the blood pressure of experimental animals. Br J Pharmacol. 1970 Dec;40(4):605-16. PubMed PMID: 4322040; PubMed Central PMCID: PMC1702921. 2: Krane IM, Naylor SL, Helin-Davis D, Chin WW, Spindel ER. Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin. J Biol Chem. 1988 Sep 15;263(26):13317-23. Erratum in: J Biol Chem 1990 Apr 25;265(12):7091. PubMed PMID: 2458345. 3: Walsh JH, Lechago J, Wong HC, Rosenquist GL. Presence of ranatensin-like and bombesin-like peptides in amphibian brains. Regul Pept. 1982 Jan;3(1):1-13. PubMed PMID: 6172810. 4: Chronwall BM, Pisano JJ, Bishop JF, Moody TW, O'Donohue TL. Biochemical and histochemical characterization of ranatensin immunoreactive peptides in rat brain: lack of coexistence with bombesin/GRP. Brain Res. 1985 Jul 8;338(1):97-113. PubMed PMID: 3896395. 5: Chronwall BM, Skirboll LR, O'Donohue TL. Demonstration of a pontine-hippocampal projection containing a ranatensin-like peptide. Neurosci Lett. 1985 Jan 7;53(1):109-14. PubMed PMID: 3887223. 6: Clineschmidt BV, Geller RG, Govier WC, Pisano JJ, Tanimura T. Effects of ranatensin, a polypeptide from frog skin, on isolated smooth muscle. Br J Pharmacol. 1971 Apr;41(4):622-8. PubMed PMID: 4325450; PubMed Central PMCID: PMC1702775. 7: Modlin IM, Lamers CB, Walsh JH. Stimulation of canine pancreatic polypeptide, gastrin, and gastric acid secretion by ranatensin, litorin, bombesin nonapeptide and substance P. Regul Pept. 1981 Jan;1(4):279-88. PubMed PMID: 6166964. 8: Spindel ER, Krane IM. Molecular biology of bombesin-like peptides. Comparison of cDNAs encoding human gastrin-releasing peptide, human neuromedin B, and amphibian ranatensin. Ann N Y Acad Sci. 1988;547:10-20. Review. PubMed PMID: 3071215. 9: de Caro G, Massi M, Micossi LG, Perfumi M. Drinking and feeding inhibition by ICV pulse injection or infusion of bombesin, ranatensin and litorin to rats. Peptides. 1984 May-Jun;5(3):607-13. PubMed PMID: 6473174. 10: Louis WJ, Tanimura T, Pisano JJ. The relationship between the vascular responses to the peptides ranatensin and angiotensin. Eur J Pharmacol. 1971 May;14(4):340-3. PubMed PMID: 4333701. 11: Moody TW, Getz R, O'Donohue TL, Rosenstein JM. Localization of receptors for bombesin-like peptides in the rat brain. Ann N Y Acad Sci. 1988;547:114-30. PubMed PMID: 2853589. 12: Yasuhara T, Ishikawa O, Nakajima T. The studies on the active peptide in the skin of Rana rugosa. II. The structure of ranatensin-R, the new ranatensin analogue, and granuliberin-R, the new mast cell degranulating peptide. Chem Pharm Bull (Tokyo). 1979 Feb;27(2):492-8. PubMed PMID: 445685. 13: Zhu XZ, Ji XQ, Wu SX, Zou G. Sulpiride attenuates ranatensin-M-induced antinociception. Zhongguo Yao Li Xue Bao. 1991 Jul;12(4):291-3. PubMed PMID: 1807073. 14: Houben H, Denef C. Stimulation of growth hormone and prolactin release from rat pituitary cell aggregates by bombesin- and ranatensin-like peptides is potentiated by estradiol, 5 alpha-dihydrotestosterone, and dexamethasone. Endocrinology. 1990 May;126(5):2257-66. PubMed PMID: 2328688. 15: Lin Y, Chen T, Zhou M, Wang L, Su S, Shaw C. Ranatensin-HL: A Bombesin-Related Tridecapeptide from the Skin Secretion of the Broad-Folded Frog, Hylarana latouchii. Molecules. 2017 Jul 4;22(7). pii: E1110. doi: 10.3390/molecules22071110. PubMed PMID: 28677620. 16: Lin JY, Pan JT. Stimulatory effects of bombesin-like peptides on hypothalamic arcuate neurons in rat brain slices. Brain Res Bull. 1994;35(3):241-6. PubMed PMID: 7812804. 17: Ali M, Gawin AZ, Baraniuk JN. Effects of bombesin family peptides and antagonists on guinea pig nasal mucosal secretion. J Pharmacol Exp Ther. 1996 Mar;276(3):1266-71. PubMed PMID: 8786559. 18: Panzanelli P, Mulatero B, Lazarus LH, Fasolo A. Neuromedin B-like immunoreactivity in the brain of the green frog (Rana esculenta L.). Eur J Basic Appl Histochem. 1991;35(4):359-70. PubMed PMID: 1801930. 19: Howard JM, Jensen RT, Gardner JD. Bombesin-induced residual stimulation of amylase release from mouse pancreatic acini. Am J Physiol. 1985 Feb;248(2 Pt 1):G196-9. PubMed PMID: 2578744. 20: Lee PC, Jensen RT, Gardner JD. Bombesin-induced desensitization of enzyme secretion in dispersed acini from guinea pig pancreas. Am J Physiol. 1980 Mar;238(3):G213-8. PubMed PMID: 6154421.