MedKoo Cat#: 532859 | Name: UCCF-853
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

UCCF-853 is an activator of the CFTR Cl- channel which may be useful for therapy of cystic fibrosis.

Chemical Structure

UCCF-853
UCCF-853
CAS#625458-06-2

Theoretical Analysis

MedKoo Cat#: 532859

Name: UCCF-853

CAS#: 625458-06-2

Chemical Formula: C14H8ClF3N2O

Exact Mass: 312.0277

Molecular Weight: 312.68

Elemental Analysis: C, 53.78; H, 2.58; Cl, 11.34; F, 18.23; N, 8.96; O, 5.12

Price and Availability

Size Price Availability Quantity
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
100mg USD 1,250.00 2 Weeks
200mg USD 1,950.00 2 Weeks
500mg USD 2,950.00 2 Weeks
1g USD 4,450.00 2 Weeks
2g USD 6,850.00 2 Weeks
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Related CAS #
No Data
Synonym
UCCF-853; UCCF 853; UCCF853
IUPAC/Chemical Name
1-(3-chlorophenyl)-5-(trifluoromethyl)-2,3-dihydro-1H-1,3-benzodiazol-2-one
InChi Key
NMPJFFWYEIIGFW-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H8ClF3N2O/c15-9-2-1-3-10(7-9)20-12-5-4-8(14(16,17)18)6-11(12)19-13(20)21/h1-7H,(H,19,21)
SMILES Code
O=C1N(C2=CC=CC(Cl)=C2)C3=CC=C(C(F)(F)F)C=C3N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 312.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Caci E, Folli C, Zegarra-Moran O, Ma T, Springsteel MF, Sammelson RE, Nantz MH, Kurth MJ, Verkman AS, Galietta LJ. CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds. Am J Physiol Lung Cell Mol Physiol. 2003 Jul;285(1):L180-8. Epub 2003 Mar 21. PubMed PMID: 12651632.