MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 525447 | Name: Rbin-2
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Rbin-2 is a novel cell penetrant, potent, selective and reversible inhibitor of Midasin, inhibiting eukaryotic ribosome biogenesis and directly targeting AAA+ ATPase Midasin. Rbin-2 is a potent Rbin-1 analog that is likely to have a similar mechanism of action. RBIN-2 results in inhibition of Mdn1’s steady-state ATPase activity.

Chemical Structure

Rbin-2
Rbin-2
CAS#2032282-97-4

Theoretical Analysis

MedKoo Cat#: 525447

Name: Rbin-2

CAS#: 2032282-97-4

Chemical Formula: C13H11BrN4S

Exact Mass: 333.9888

Molecular Weight: 335.22

Elemental Analysis: C, 46.58; H, 3.31; Br, 23.84; N, 16.71; S, 9.56

Price and Availability

Size Price Availability Quantity
100mg USD 1,350.00 2 Weeks
200mg USD 2,150.00 2 Weeks
500mg USD 3,650.00 2 Weeks
1g USD 5,450.00 2 Weeks
2g USD 9,250.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
2032282-97-4
Synonym
Rbin-2; Rbin2; Rbin 2
IUPAC/Chemical Name
7-Bromo-2-(2-methyl-allylsulfanyl)-9H-1,3,4,9-tetraaza-fluorene
InChi Key
OVDAOBDZJJZJMY-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H11BrN4S/c1-7(2)6-19-13-16-12-11(17-18-13)9-4-3-8(14)5-10(9)15-12/h3-5H,1,6H2,2H3,(H,15,16,18)
SMILES Code
C=C(C)CSC1=NN=C2C(NC3=C2C=CC(Br)=C3)=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Rbin-2 is a potent, reversible and selective inhibitor of Midasin (Mdn1. Rbin-2 inhibits eukaryotic ribosome biogenesis and is a powerful probe for the eukaryotic ribosome assembly.
In vitro activity:
Analyses of Rbin sensitivity and resistance conferring mutations in fission yeast, as well as biochemical assays with recombinant proteins, provide evidence that Rbins' physiological target is Midasin. The findings of this study demonstrate that Rbins are powerful probes for eukaryotic ribosome assembly. Reference: Cell. 2016 Oct 6;167(2):512-524.e14. https://pubmed.ncbi.nlm.nih.gov/27667686/
In vivo activity:
To be determined
Solvent mg/mL mM
Solubility
DMSO 1.0 2.98
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 335.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Kawashima SA, Chen Z, Aoi Y, Patgiri A, Kobayashi Y, Nurse P, Kapoor TM. Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis. Cell. 2016 Oct 6;167(2):512-524.e14. doi: 10.1016/j.cell.2016.08.070. Epub 2016 Sep 22. PMID: 27667686; PMCID: PMC5116814.
In vitro protocol:
1. Kawashima SA, Chen Z, Aoi Y, Patgiri A, Kobayashi Y, Nurse P, Kapoor TM. Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis. Cell. 2016 Oct 6;167(2):512-524.e14. doi: 10.1016/j.cell.2016.08.070. Epub 2016 Sep 22. PMID: 27667686; PMCID: PMC5116814.
In vivo protocol:
To be determined
1: Kawashima, S. A., Chen, Z., Aoi, Y., Patgiri, A., Kobayashi, Y., Nurse, P., & Kapoor, T. M. (2016). Potent, reversible, and specific chemical inhibitors of eukaryotic ribosome biogenesis. Cell, 167(2), 512-524.