Synonym
IWP-L6; IWP L6; IWPL6; PORCN Inhibitor III; Wnt Pathway Inhibitor XIX.
IUPAC/Chemical Name
N-(5-phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
InChi Key
QESQGTFWEQMCMH-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H20N4O2S2/c30-22(28-21-12-11-18(15-26-21)17-7-3-1-4-8-17)16-33-25-27-20-13-14-32-23(20)24(31)29(25)19-9-5-2-6-10-19/h1-12,15H,13-14,16H2,(H,26,28,30)
SMILES Code
O=C(NC1=NC=C(C2=CC=CC=C2)C=C1)CSC3=NC(CCS4)=C4C(N3C5=CC=CC=C5)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
472.58
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: You L, Zhang C, Yarravarapu N, Morlock L, Wang X, Zhang L, Williams NS, Lum L,
Chen C. Development of a triazole class of highly potent Porcn inhibitors. Bioorg
Med Chem Lett. 2016 Dec 15;26(24):5891-5895. doi: 10.1016/j.bmcl.2016.11.012.
Epub 2016 Nov 11. PubMed PMID: 27876319; PubMed Central PMCID: PMC5142825.
2: Wang X, Moon J, Dodge ME, Pan X, Zhang L, Hanson JM, Tuladhar R, Ma Z, Shi H,
Williams NS, Amatruda JF, Carroll TJ, Lum L, Chen C. The development of highly
potent inhibitors for porcupine. J Med Chem. 2013 Mar 28;56(6):2700-4. doi:
10.1021/jm400159c. Epub 2013 Mar 19. PubMed PMID: 23477365; PubMed Central PMCID:
PMC3631274.
3: Gao X, Hannoush RN. Single-cell imaging of Wnt palmitoylation by the
acyltransferase porcupine. Nat Chem Biol. 2014 Jan;10(1):61-8. doi:
10.1038/nchembio.1392. Epub 2013 Nov 24. PubMed PMID: 24292069.
