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MedKoo Cat#: 525376 | Name: LCAHA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LCAHA is a novel inhibitor of USP2a, inhibiting growth of cyclin D1-dependent cells at submicromolar concentrations and being independent of p53 status.

Chemical Structure

LCAHA
LCAHA
CAS#117094-40-3

Theoretical Analysis

MedKoo Cat#: 525376

Name: LCAHA

CAS#: 117094-40-3

Chemical Formula: C24H41NO3

Exact Mass: 391.3086

Molecular Weight: 391.60

Elemental Analysis: C, 73.61; H, 10.55; N, 3.58; O, 12.26

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
LCAHA
IUPAC/Chemical Name
Lithocholic acid hydroxyamide
InChi Key
WZXAGWREMCSWMF-YPLGJCPNSA-N
InChi Code
InChI=1S/C24H41NO3/c1-15(4-9-22(27)25-28)19-7-8-20-18-6-5-16-14-17(26)10-12-23(16,2)21(18)11-13-24(19,20)3/h15-21,26,28H,4-14H2,1-3H3,(H,25,27)/t15-,16?,17-,18+,19-,20+,21+,23+,24-/m1/s1
SMILES Code
O[C@@H]1CC[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@H]([C@H](C)CCC(NO)=O)CC[C@@]4([H])[C@]3([H])CCC2C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 391.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Samec P, Caha J, Zapletal M, Tuček P, Cudlín P, Kučera M. Discrimination between acute and chronic decline of Central European forests using map algebra of the growth condition and forest biomass fuzzy sets: A case study. Sci Total Environ. 2017 May 10;599-600:899-909. doi: 10.1016/j.scitotenv.2017.05.023. [Epub ahead of print] PubMed PMID: 28501014. 2: Zeleník K, Walderová R, Kučová H, Jančatová D, Komínek P. Comparison of long-term voice outcomes after vocal fold augmentation using autologous fat injection by direct microlaryngoscopy versus office-based calcium hydroxylapatite injection. Eur Arch Otorhinolaryngol. 2017 May 6. doi: 10.1007/s00405-017-4600-1. [Epub ahead of print] PubMed PMID: 28478500. 3: Kadouch JA. Calcium hydroxylapatite: A review on safety and complications. J Cosmet Dermatol. 2017 Mar 1. doi: 10.1111/jocd.12326. [Epub ahead of print] Review. PubMed PMID: 28247924. 4: Yutskovskaya YA, Kogan EA. Improved Neocollagenesis and Skin Mechanical Properties After Injection of Diluted Calcium Hydroxylapatite in the Neck and Décolletage:A Pilot Study. J Drugs Dermatol. 2017 Jan 1;16(1):68-74. PubMed PMID: 28095536. 5: Eftekharzadeh S, Sabetkish N, Sabetkish S, Kajbafzadeh AM. Comparing the bulking effect of calcium hydroxyapatite and Deflux injection into the bladder neck for improvement of urinary incontinence in bladder exstrophy-epispadias complex. Int Urol Nephrol. 2017 Feb;49(2):183-189. doi: 10.1007/s11255-016-1464-z. Epub 2016 Nov 28. PubMed PMID: 27896576. 6: Volobuev VV, Mandal PS, Galicka M, Caha O, Sánchez-Barriga J, Di Sante D, Varykhalov A, Khiar A, Picozzi S, Bauer G, Kacman P, Buczko R, Rader O, Springholz G. Giant Rashba Splitting in Pb(1-)(x) Sn(x) Te (111) Topological Crystalline Insulator Films Controlled by Bi Doping in the Bulk. Adv Mater. 2017 Jan;29(3). doi: 10.1002/adma.201604185. Epub 2016 Nov 17. PubMed PMID: 27859857. 7: Rousidou C, Karaiskos D, Myti D, Karanasios E, Karas PA, Tourna M, Tzortzakakis EA, Karpouzas DG. Distribution and function of carbamate hydrolase genes cehA and mcd in soils: the distinct role of soil pH. FEMS Microbiol Ecol. 2017 Jan 1;93(1). doi: 10.1093/femsec/fiw219. PubMed PMID: 27797966. 8: Akrap A, Hakl M, Tchoumakov S, Crassee I, Kuba J, Goerbig MO, Homes CC, Caha O, Novák J, Teppe F, Desrat W, Koohpayeh S, Wu L, Armitage NP, Nateprov A, Arushanov E, Gibson QD, Cava RJ, van der Marel D, Piot BA, Faugeras C, Martinez G, Potemski M, Orlita M. Magneto-Optical Signature of Massless Kane Electrons in Cd_{3}As_{2}. Phys Rev Lett. 2016 Sep 23;117(13):136401. Epub 2016 Sep 21. PubMed PMID: 27715109. 9: Rey de Castro J, Liendo A, Ortiz O, Rosales-Mayor E, Liendo C. Ventilatory Cycle Measurements and Loop Gain in Central Apnea in Mining Drivers Exposed to Intermittent Altitude. J Clin Sleep Med. 2017 Jan 15;13(1):27-32. doi: 10.5664/jcsm.6380. PubMed PMID: 27707449; PubMed Central PMCID: PMC5181610. 10: Fabi SG, Burgess C, Carruthers A, Carruthers J, Day D, Goldie K, Kerscher M, Nikolis A, Pavicic T, Rho NK, Rzany B, Sattler S, Seo K, Werschler WP, Sattler G. Consensus Recommendations for Combined Aesthetic Interventions Using Botulinum Toxin, Fillers, and Microfocused Ultrasound in the Neck, Décolletage, Hands, and Other Areas of the Body. Dermatol Surg. 2016 Oct;42(10):1199-1208. PubMed PMID: 27668925. 11: Aguilera SB, Aristizabal M, Reed A. Successful Treatment of Calcium Hydroxylapatite Nodules With Intralesional 5-Fluorouracil, Dexamethasone, and Triamcinolone. J Drugs Dermatol. 2016 Sep 1;15(9):1142-3. PubMed PMID: 27602980. 12: Meland M, Groppi C, Lorenc ZP. Rheological Properties of Calcium Hydroxylapatite With Integral Lidocaine. J Drugs Dermatol. 2016 Sep 1;15(9):1107-10. PubMed PMID: 27602973. 13: Caffier PP, I Nasr A, Weikert S, Rummich J, Gross M, Nawka T. The use of injectable calcium hydroxylapatite in the surgically pretreated larynx with glottal insufficiency. Laryngoscope. 2017 May;127(5):1125-1130. doi: 10.1002/lary.26261. Epub 2016 Aug 31. PubMed PMID: 27578371. 14: Schachter D, Bertucci V, Solish N. Calcium Hydroxylapatite With Integral Lidocaine Provides Improved Pain Control for the Correction of Nasolabial Folds. J Drugs Dermatol. 2016 Aug 1;15(8):1005-10. PubMed PMID: 27538003. 15: Lee JC, Lorenc ZP. Synthetic Fillers for Facial Rejuvenation. Clin Plast Surg. 2016 Jul;43(3):497-503. doi: 10.1016/j.cps.2016.03.002. Review. PubMed PMID: 27363763. 16: Tavares-da-Silva EJ, Varela CL, Pires AS, Encarnação JC, Abrantes AM, Botelho MF, Carvalho RA, Proença C, Freitas M, Fernandes E, Roleira FM. Combined dual effect of modulation of human neutrophils' oxidative burst and inhibition of colon cancer cells proliferation by hydroxycinnamic acid derivatives. Bioorg Med Chem. 2016 Aug 15;24(16):3556-64. doi: 10.1016/j.bmc.2016.05.065. Epub 2016 May 30. PubMed PMID: 27290693. 17: Mitra A, Guèvremont G, Timofeeva E. Stress and Sucrose Intake Modulate Neuronal Activity in the Anterior Hypothalamic Area in Rats. PLoS One. 2016 May 31;11(5):e0156563. doi: 10.1371/journal.pone.0156563. eCollection 2016. PubMed PMID: 27243579; PubMed Central PMCID: PMC4887034. 18: Shi XH, Zhou X, Zhang YM, Lei ZY, Liu T, Fan DL. Complications from Nasolabial Fold Injection of Calcium Hydroxylapatite for Facial Soft-Tissue Augmentation: A Systematic Review and Meta-Analysis. Aesthet Surg J. 2016 Jun;36(6):712-7. doi: 10.1093/asj/sjv206. Review. PubMed PMID: 27178901. 19: Fabi SG, Goldman MP, Mills DC, Werschler WP, Green JB, Kaufman J, Weiss RA, Hornfeldt CS. Combining Microfocused Ultrasound With Botulinum Toxin and Temporary and Semi-Permanent Dermal Fillers: Safety and Current Use. Dermatol Surg. 2016 May;42 Suppl 2:S168-76. doi: 10.1097/DSS.0000000000000751. PubMed PMID: 27128245. 20: Courderot-Masuyer C, Robin S, Tauzin H, Humbert P. Evaluation of lifting and antiwrinkle effects of calcium hydroxylapatite filler. In vitro quantification of contractile forces of human wrinkle and normal aged fibroblasts treated with calcium hydroxylapatite. J Cosmet Dermatol. 2016 Sep;15(3):260-8. doi: 10.1111/jocd.12215. Epub 2016 Mar 17. PubMed PMID: 26990784.