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MedKoo Cat#: 530667 | Name: SC-79
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SC-79 is an activator of Akt that blocks its membrane translocation while allowing its phosphorylation, in the cytosol, by upstream kinases. SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral head. SC-79 injections inhibited alcohol-induced osteonecrosis. Alcohol-induced ONFH is associated with suppression of p-Akt-Ser473 in the Akt/GSK3β/β-catenin signaling pathway in bone mesenchymal stem cells.

Chemical Structure

SC-79
SC-79
CAS#305834-79-1

Theoretical Analysis

MedKoo Cat#: 530667

Name: SC-79

CAS#: 305834-79-1

Chemical Formula: C17H17ClN2O5

Exact Mass: 364.0826

Molecular Weight: 364.78

Elemental Analysis: C, 55.98; H, 4.70; Cl, 9.72; N, 7.68; O, 21.93

Price and Availability

Size Price Availability Quantity
50mg USD 250.00
100mg USD 450.00
200mg USD 750.00
500mg USD 1,450.00
1g USD 2,250.00
2g USD 3,950.00
5g USD 5,950.00
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Related CAS #
No Data
Synonym
SC-79; SC 79; SC79.
IUPAC/Chemical Name
ethyl 2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
InChi Key
DXVKFBGVVRSOLI-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H17ClN2O5/c1-3-23-16(21)11(8-19)13-10-7-9(18)5-6-12(10)25-15(20)14(13)17(22)24-4-2/h5-7,11,13H,3-4,20H2,1-2H3
SMILES Code
NC1=C(C(OCC)=O)C(C(C(OCC)=O)C#N)C2=CC(Cl)=CC=C2O1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
SC-79 treatment to rescue Akt activation could be tested in the clinic as a potential therapeutic approach to preventing the development of alcohol-induced ONFH.
Product Data
Product Data
Instruction
View handling instruction
Biological target:
SC-79 activates Akt in the cytosol by specifically binding to the PH domain of Akt. SC-79 inhibits Akt membrane translocation.
In vitro activity:
SC-79 is a promising avenue for mitigating neuronal damage in Parkinson's disease by targeting mitochondrial dysfunction and oxidative stress through Akt-Nrf2 activation. In SH-SY5Y cells and primary murine DA neurons, SC-79 attenuated adverse effects induced by the mitochondrial toxins MPP+- and rotenone, such as cell viability, death, and apoptosis. SC-79 also attenuated MPP+- and rotenone-induced ROS production, mitochondrial depolarization, and lipid peroxidation. Reference: Mol Cell Biochem. 2019 Nov;461(1-2):81-89. https://pubmed.ncbi.nlm.nih.gov/31342299/
In vivo activity:
SC-79 treatment could be a potential therapeutic approach to preventing the development of alcohol-induced osteonecrosis of the femoral head. In a rat model, SC-79 injections inhibited alcohol-induced osteonecrosis. Reference: Oncotarget. 2017 May 9;8(19):31065-31078. https://pubmed.ncbi.nlm.nih.gov/28415692/
Solvent mg/mL mM
Solubility
DMSO 73.0 200.12
Ethanol 36.0 98.69
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 364.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Zhu JL, Wu YY, Wu D, Luo WF, Zhang ZQ, Liu CF. SC79, a novel Akt activator, protects dopaminergic neuronal cells from MPP+ and rotenone. Mol Cell Biochem. 2019 Nov;461(1-2):81-89. doi: 10.1007/s11010-019-03592-x. Epub 2019 Jul 24. PMID: 31342299. 2. Xu Y, Gao YW, Yang Y. SC79 protects dopaminergic neurons from oxidative stress. Oncotarget. 2017 Dec 20;9(16):12639-12648. doi: 10.18632/oncotarget.23538. PMID: 29560097; PMCID: PMC5849161. 3. Luan Q, Pan L, He D, Gong X, Zhou H. SC79, the AKT Activator Protects Cerebral Ischemia in a Rat Model of Ischemia/Reperfusion Injury. Med Sci Monit. 2018 Aug 3;24:5391-5397. doi: 10.12659/MSM.910191. PMID: 30074018; PMCID: PMC6087033. 4. Chen YX, Tao SC, Xu ZL, Yin WJ, Zhang YL, Yin JH, Gao YS, Zhang CQ. Novel Akt activator SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral head. Oncotarget. 2017 May 9;8(19):31065-31078. doi: 10.18632/oncotarget.16075. PMID: 28415692; PMCID: PMC5458189.
In vitro protocol:
1. Zhu JL, Wu YY, Wu D, Luo WF, Zhang ZQ, Liu CF. SC79, a novel Akt activator, protects dopaminergic neuronal cells from MPP+ and rotenone. Mol Cell Biochem. 2019 Nov;461(1-2):81-89. doi: 10.1007/s11010-019-03592-x. Epub 2019 Jul 24. PMID: 31342299. 2. Xu Y, Gao YW, Yang Y. SC79 protects dopaminergic neurons from oxidative stress. Oncotarget. 2017 Dec 20;9(16):12639-12648. doi: 10.18632/oncotarget.23538. PMID: 29560097; PMCID: PMC5849161.
In vivo protocol:
1. Luan Q, Pan L, He D, Gong X, Zhou H. SC79, the AKT Activator Protects Cerebral Ischemia in a Rat Model of Ischemia/Reperfusion Injury. Med Sci Monit. 2018 Aug 3;24:5391-5397. doi: 10.12659/MSM.910191. PMID: 30074018; PMCID: PMC6087033. 2. Chen YX, Tao SC, Xu ZL, Yin WJ, Zhang YL, Yin JH, Gao YS, Zhang CQ. Novel Akt activator SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral head. Oncotarget. 2017 May 9;8(19):31065-31078. doi: 10.18632/oncotarget.16075. PMID: 28415692; PMCID: PMC5458189.
1: Kovács B, Szapáry L, Kajos FL, Jozifek JE, Erdősi P, Szántóri P, Boncz I. Rekanalizációs beavatkozással kezelt, akut ischaemiás stroke-os betegek életminősége [Quality of life in acute ischaemic stroke patients treated with recanalisation]. Ideggyogy Sz. 2024 Sep 30;77(9-10):315-322. Hungarian. doi: 10.18071/isz.77.0315. PMID: 39352260. 2: Zhang Z, Guo Y, Gao X, Wang X, Jin C. Role of histone methyltransferase KMT2D in BMSC osteogenesis via AKT signaling. Regen Ther. 2024 Sep 10;26:775-782. doi: 10.1016/j.reth.2024.08.022. PMID: 39309396; PMCID: PMC11414574. 3: Zhao J, Gao G, Ding J, Liu W, Wang T, Zhao L, Xu J, Zhang Z, Zhang X, Xie Z. Astragaloside I Promotes Lipophagy and Mitochondrial Biogenesis to Improve Hyperlipidemia by Regulating Akt/mTOR/TFEB Pathway. J Agric Food Chem. 2024 Oct 2;72(39):21548-21559. doi: 10.1021/acs.jafc.4c03172. Epub 2024 Sep 3. PMID: 39226078. 4: Wang Y, Chen SJ, Ma T, Long Q, Chen L, Xu KX, Cao Y. Promotion of apoptosis in melanoma cells by taxifolin through the PI3K/AKT signaling pathway: Screening of natural products using WGCNA and CMAP platforms. Int Immunopharmacol. 2024 Sep 10;138:112517. doi: 10.1016/j.intimp.2024.112517. Epub 2024 Jun 25. PMID: 38924866. 5: Deng ZT, Liang SF, Huang GK, Wang YQ, Tu XY, Zhang YN, Li S, Liu T, Cheng BB. Autophagy plays a pro-apoptotic role in arsenic trioxide-induced cell death of liver cancer. J Integr Med. 2024 May;22(3):295-302. doi: 10.1016/j.joim.2024.03.011. Epub 2024 Mar 29. PMID: 38599914. 6: Zhu SL, Qi M, Chen MT, Lin JP, Huang HF, Deng LJ, Zhou XW. A novel DDIT3 activator dehydroevodiamine effectively inhibits tumor growth and tumor cell stemness in pancreatic cancer. Phytomedicine. 2024 Jun;128:155377. doi: 10.1016/j.phymed.2024.155377. Epub 2024 Jan 19. PMID: 38503154. 7: Que Y, Wong C, Qiu J, Gao W, Lin Y, Zhou H, Gao B, Li P, Deng Z, Shi H, Hu W, Liu S, Peng Y, Su P, Xu C, Liang A, Qiu X, Huang D. Maslinic acid alleviates intervertebral disc degeneration by inhibiting the PI3K/AKT and NF-κB signaling pathways. Acta Biochim Biophys Sin (Shanghai). 2024 May 25;56(5):776-788. doi: 10.3724/abbs.2024027. PMID: 38495003; PMCID: PMC11187486. 8: Zheng Z, Zhao X, Yuan B, Jiang S, Yan R, Dong X, Yao Q, Liang H. Soy isoflavones induces mitophagy to inhibit the progression of osteosarcoma by blocking the AKT/mTOR signaling pathway. Mol Med. 2024 Jan 8;30(1):5. doi: 10.1186/s10020-024-00778-y. PMID: 38191316; PMCID: PMC10775635. 9: Sun W, Li W, Zhang M, Du Q. Dexmedetomidine Protects Cortical Neurons from Propofol-Induced Apoptosis via Activation of Akt-IKK-NF-κB Signaling Pathway by α2A-adrenoceptor. Appl Biochem Biotechnol. 2024 Aug;196(8):4849-4861. doi: 10.1007/s12010-023-04768-4. Epub 2023 Nov 18. PMID: 37979083. 10: Gong H, Lyu X, Liu Y, Peng N, Tan S, Dong L, Zhang X. Eupatilin inhibits pulmonary fibrosis by activating Sestrin2/PI3K/Akt/mTOR dependent autophagy pathway. Life Sci. 2023 Dec 1;334:122218. doi: 10.1016/j.lfs.2023.122218. Epub 2023 Nov 1. PMID: 37918625. 11: Mao L, Schneider JW, Robinson AS. Rosmarinic acid enhances CHO cell productivity and proliferation through activation of the unfolded protein response and the mTOR pathway. Biotechnol J. 2024 Jan;19(1):e2300397. doi: 10.1002/biot.202300397. Epub 2023 Nov 15. PMID: 37897814. 12: Bazzone A, Barthmes M, George C, Brinkwirth N, Zerlotti R, Prinz V, Cole K, Friis S, Dickson A, Rice S, Lim J, Fern Toh M, Mohammadi M, Pau D, Stone DJ, Renger JJ, Fertig N. A Comparative Study on the Lysosomal Cation Channel TMEM175 Using Automated Whole-Cell Patch-Clamp, Lysosomal Patch-Clamp, and Solid Supported Membrane-Based Electrophysiology: Functional Characterization and High-Throughput Screening Assay Development. Int J Mol Sci. 2023 Aug 14;24(16):12788. doi: 10.3390/ijms241612788. PMID: 37628970; PMCID: PMC10454728. 13: Wang C, Cao F, Cao J, Jiao Z, You Y, Xiong Y, Zhao W, Wang X. CD58 acts as a tumor promotor in hepatocellular carcinoma via activating the AKT/GSK-3β/β-catenin pathway. J Transl Med. 2023 Aug 12;21(1):539. doi: 10.1186/s12967-023-04364-4. PMID: 37573318; PMCID: PMC10422835. 14: Chang S, Zhuang Z, Jin C. MetaLnc9 facilitates osteogenesis of human bone marrow mesenchymal stem cells by activating the AKT pathway. Connect Tissue Res. 2023 Nov;64(6):532-542. doi: 10.1080/03008207.2023.2232463. Epub 2023 Jul 10. PMID: 37427853. 15: Yao H, Du Y, Jiang B, Liao Y, Zhao Y, Yin M, Li T, Sheng Y, Ji Y, Du M. Sulforaphene suppresses RANKL-induced osteoclastogenesis and LPS-induced bone erosion by activating Nrf2 signaling pathway. Free Radic Biol Med. 2023 Oct;207:48-62. doi: 10.1016/j.freeradbiomed.2023.07.009. Epub 2023 Jul 7. PMID: 37423561. 16: Wang M, Qiu C, Pan Q, Yang Y, Yang D, Sun X. Role of Nuclear Receptor Subfamily 1 Group D Member 1 in the Proliferation, Migration of Vascular Smooth Muscle Cell, and Vascular Intimal Hyperplasia. J Cardiovasc Pharmacol. 2023 Sep 1;82(3):221-228. doi: 10.1097/FJC.0000000000001446. PMID: 37381169. 17: Song Y, Wu Q. RBM15 m6 A modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling. Environ Toxicol. 2023 Sep;38(9):2155-2164. doi: 10.1002/tox.23852. Epub 2023 Jun 19. PMID: 37334762. 18: Tang Q, Markby GR, MacNair AJ, Tang K, Tkacz M, Parys M, Phadwal K, MacRae VE, Corcoran BM. TGF-β-induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease. Cell Prolif. 2023 Jun;56(6):e13435. doi: 10.1111/cpr.13435. Epub 2023 Mar 4. PMID: 36869852; PMCID: PMC10280140. 19: Peng J, Xiao X, Li S, Lyu X, Gong H, Tan S, Dong L, Sanders YY, Zhang X. Aspirin alleviates pulmonary fibrosis through PI3K/AKT/mTOR-mediated autophagy pathway. Exp Gerontol. 2023 Feb;172:112085. doi: 10.1016/j.exger.2023.112085. Epub 2023 Jan 7. PMID: 36623738. 20: Fan X, He Y, Wu G, Chen H, Cheng X, Zhan Y, An C, Chen T, Wang X. Sirt3 activates autophagy to prevent DOX-induced senescence by inactivating PI3K/AKT/mTOR pathway in A549 cells. Biochim Biophys Acta Mol Cell Res. 2023 Feb;1870(2):119411. doi: 10.1016/j.bbamcr.2022.119411. Epub 2022 Dec 12. PMID: 36521686.

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