SRA880 free base |NVP SRA880 | CAS#187218-90-2

MedKoo Cat#: 532790 | Name: SRA880 free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SRA880 is a non-peptide somatostatin sst(1) receptor antagonist. SRA880 displayed significantly lower affinity for the other human recombinant somatostatin receptors ( pK(d) < or = 6.0) or a wide range of neurotransmitter receptors, except for the human dopamine D4 receptors. SRA880 positively modulates release of endogenous SRIF, was found to synergize with imipramine in causing antidepressant-like effects in the tail suspension test.

Chemical Structure

SRA880 free base

CAS#187218-90-2 (free base)

Theoretical Analysis

MedKoo Cat#: 532790

Name: SRA880 free base

CAS#: 187218-90-2 (free base)

Chemical Formula: C26H32N4O4

Exact Mass: 464.2424

Molecular Weight: 464.57

Elemental Analysis: C, 67.22; H, 6.94; N, 12.06; O, 13.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

187218-90-2 (free base) 573984-99-3 (malonate) 944391-14-4 (HCl)

Synonym

SRA880; SRA 880; SRA-880; NVP-SRA880; NVP SRA880; NVPSRA880.

IUPAC/Chemical Name

[(3R,4aR,10aR)-6-methoxy-1-methyl-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinolin-3-yl]-[4-(4-nitrophenyl)piperazin-1-yl]methanone

InChi Key

INULNSAIIZKOQE-YOSAUDMPSA-N

InChi Code

InChI=1S/C26H32N4O4/c1-27-17-20(14-19-15-23-18(16-24(19)27)4-3-5-25(23)34-2)26(31)29-12-10-28(11-13-29)21-6-8-22(9-7-21)30(32)33/h3-9,19-20,24H,10-17H2,1-2H3/t19-,20-,24-/m1/s1

SMILES Code

O=C([C@H]1CN(C)[C@]2([H])CC3=CC=CC(OC)=C3C[C@@]2([H])C1)N4CCN(C5=CC=C([N+]([O-])=O)C=C5)CC4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 464.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Nilsson A, Stroth N, Zhang X, Qi H, Fälth M, Sköld K, Hoyer D, Andrén PE, Svenningsson P. Neuropeptidomics of mouse hypothalamus after imipramine treatment reveal somatostatin as a potential mediator of antidepressant effects. Neuropharmacology. 2012 Jan;62(1):347-57. doi: 10.1016/j.neuropharm.2011.08.004. Epub 2011 Aug 16. PubMed PMID: 21856315. 2: De Bundel D, Aourz N, Kiagiadaki F, Clinckers R, Hoyer D, Kastellakis A, Michotte Y, Thermos K, Smolders I. Hippocampal sst(1) receptors are autoreceptors and do not affect seizures in rats. Neuroreport. 2010 Mar 10;21(4):254-8. doi: 10.1097/WNR.0b013e3283353a64. PubMed PMID: 20134357. 3: Foong JP, Parry LJ, Gwynne RM, Bornstein JC. 5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum. Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G384-94. doi: 10.1152/ajpgi.00438.2009. Epub 2009 Dec 10. PubMed PMID: 20007849; PubMed Central PMCID: PMC2838515. 4: Marazioti A, Pitychoutis PM, Papadopoulou-Daifoti Z, Spyraki C, Thermos K. Activation of somatostatin receptors in the globus pallidus increases rat locomotor activity and dopamine release in the striatum. Psychopharmacology (Berl). 2008 Dec;201(3):413-22. doi: 10.1007/s00213-008-1305-6. Epub 2008 Sep 3. PubMed PMID: 18766330. 5: Marazioti A, Kastellakis A, Antoniou K, Papasava D, Thermos K. Somatostatin receptors in the ventral pallidum/substantia innominata modulate rat locomotor activity. Psychopharmacology (Berl). 2005 Sep;181(2):319-26. Epub 2005 Oct 14. PubMed PMID: 15778878. 6: Hoyer D, Nunn C, Hannon J, Schoeffter P, Feuerbach D, Schuepbach E, Langenegger D, Bouhelal R, Hurth K, Neumann P, Troxler T, Pfaeffli P. SRA880, in vitro characterization of the first non-peptide somatostatin sst(1) receptor antagonist. Neurosci Lett. 2004 May 6;361(1-3):132-5. PubMed PMID: 15135911.