TNIR7-1A is a High-Performance Near-Infrared Probe to Image Tau Tangles. TNIR7-1A displays properties favorable for near-infrared (NIR) imaging with high affinity and specificity to NFTs in vitro. In addition, TNIR7-1A effectively penetrated the blood-brain barrier and clearly distinguished tauopathy in transgenic mice (rTg4510) from control mice using NIR fluorescence imaging in vivo. The sensitivity and specificity of TNIR7-1A for NFTs were confirmed ex vivo by fluorescence staining of the tauopathy mouse model, while molecular docking studies indicated that TNIR7-1A bound to NFTs through hydrophobic interactions. TNIR7-1A can act as a high-performance probe to detect NFTs in vitro and in vivo selectively.
MedKoo Cat#: 130146
Name: TNIR7-1A
CAS#: 2301931-35-9
Chemical Formula: C23H20BF2N3
Exact Mass: 387.1718
Molecular Weight: 387.24
Elemental Analysis: C, 71.34; H, 5.21; B, 2.79; F, 9.81; N, 10.85
The following data is based on the product molecular weight 387.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
