SP-4206 is a IL-2Ralpha inhibitor. SP4206 (Kd approximately 70 nM) was found to block binding of the IL-2alpha receptor (IL-2Ralpha) to IL-2 (Kd approximately 10 nM). Mutational studies show that SP4206 targets virtually the same critical "hot-spot" residues on IL-2 that drive binding of IL-2Ralpha. Moreover, a mutation that enhances binding to the IL-2Ralpha near these hot spots also enhances binding to SP4206.
MedKoo Cat#: 532765
Name: SP-4206
CAS#: 515846-21-6 (free base)
Chemical Formula: C30H37Cl2N7O6
Exact Mass: 661.2182
Molecular Weight: 662.57
Elemental Analysis: C, 54.38; H, 5.63; Cl, 10.70; N, 14.80; O, 14.49
The following data is based on the product molecular weight 662.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
