MedKoo Cat#: 555965 | Name: ML266
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ML266, also known as CID-4694321, is activator of glucocerebrosidase (GCase). ML266 can serve as starting points to develop a novel approach towards small molecule treatment for patients suffering from Gaucher disease.

Chemical Structure

ML266
ML266
CAS#1462267-08-8

Theoretical Analysis

MedKoo Cat#: 555965

Name: ML266

CAS#: 1462267-08-8

Chemical Formula: C24H22BrN3O4

Exact Mass: 495.0794

Molecular Weight: 496.36

Elemental Analysis: C, 58.08; H, 4.47; Br, 16.10; N, 8.47; O, 12.89

Price and Availability

Size Price Availability Quantity
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
100mg USD 1,350.00 2 Weeks
200mg USD 2,350.00 2 Weeks
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Related CAS #
No Data
Synonym
CID-46943215; CID 46943215; CID46943215; ML266; ML 266; ML-266
IUPAC/Chemical Name
2-(2-((4-Bromophenyl)amino)-2-oxoethoxy)-N-(2-(methyl(phenyl)amino)-2-oxoethyl)benzamide
InChi Key
VAPWBKACLHRZBZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H22BrN3O4/c1-28(19-7-3-2-4-8-19)23(30)15-26-24(31)20-9-5-6-10-21(20)32-16-22(29)27-18-13-11-17(25)12-14-18/h2-14H,15-16H2,1H3,(H,26,31)(H,27,29)
SMILES Code
CN(C1=CC=CC=C1)C(CNC(C2=CC=CC=C2OCC(NC3=CC=C(C=C3)Br)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
ML266 is glucocerebrosidase (GCase) molecule chaperone with IC50 of 2.5 µM.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 496.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
Rogers S, Patnaik S, Schoenen F, Zheng W, Choi J, Motabar O, Southall N, Westbroek W, Goldin E, Sidransky E, Leister W, Marugan JJ, Aubé J. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase. 2012 Mar 27 [updated 2013 Mar 7]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 23762943.