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MedKoo Cat#: 329659 | Name: Triamcinolone acetonide
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Triamcinolone acetonide is a synthetic corticosteroid used topically to treat various skin conditions, to relieve the discomfort of mouth sores and intra-articularly by proceduralists to treat various joint conditions. In nasal spray form, it is used to treat allergic rhinitis. It is a more potent derivative of triamcinolone, and is about eight times as potent as prednisone. It is also known under the brand names Kenalog (topical) and Volon A as an injection, to treat allergies, arthritis, eye diseases, intestinal problems, and skin diseases. There are possible risks from an injection. It has been known to cause fat and muscle loss at an injection site, leaving a large divot bone deep. In 2014, the FDA made triamcinolone acetonide an over-the-counter drug in the United States in nasal spray form under the brand name Nasacort.

Chemical Structure

Triamcinolone acetonide
Triamcinolone acetonide
CAS#76-25-5 (acetonide)

Theoretical Analysis

MedKoo Cat#: 329659

Name: Triamcinolone acetonide

CAS#: 76-25-5 (acetonide)

Chemical Formula: C24H31FO6

Exact Mass: 434.2105

Molecular Weight: 434.50

Elemental Analysis: C, 66.34; H, 7.19; F, 4.37; O, 22.09

Price and Availability

Size Price Availability Quantity
100mg USD 250.00
200mg USD 450.00
500mg USD 650.00
1g USD 950.00
2g USD 1,450.00
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Related CAS #
76-25-5 (acetonide) 124-94-7 (free) 67-78-7 (diacetate) 5611-51-8 (hexacetonide)
Synonym
Triamcinolone acetonide; Kenalone; Nasacort; Acetospan; Adcortyl A; AllerNaze; Aristocort. Aristocort A. Aristocort acetonide. Aristoderm. Aristogel.
IUPAC/Chemical Name
(6aS,6bR,7S,8aS,8bS,11aR,12aS,12bS)-6b-fluoro-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-1,2,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-4H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4-one
InChi Key
YNDXUCZADRHECN-JNQJZLCISA-N
InChi Code
InChI=1S/C24H31FO6/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,25)17(28)11-22(16,4)24(19,31-20)18(29)12-26/h7-9,15-17,19,26,28H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1
SMILES Code
C[C@@]12[C@@]3(C(CO)=O)[C@H](OC(C)(O3)C)C[C@@]1([H])[C@]4([H])CCC5=CC(C=C[C@]5(C)[C@@]4(F)[C@@H](O)C2)=O
Appearance
White to off-white crystalline powder.
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 434.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Balazic E, Konisky H, Axler E, Kobets K. Concurrent Lichen Planopilaris and Female Androgenic Alopecia in Skin of Color: A Case Series. J Drugs Dermatol. 2025 Mar 1;24(3):320-322. doi: 10.36849/JDD.7318. PMID: 40043269. 2: Maity S, Vora A, Kanhed AM, Misra A, Wairkar S. Improved pharmacokinetic parameters and reduced tissue distribution of prodrug of Triamcinolone acetonide in lipid nanospheres- A preliminary investigation. Drug Dev Ind Pharm. 2025 Mar 5:1-13. doi: 10.1080/03639045.2025.2475333. Epub ahead of print. PMID: 40042166. 3: Rutnin S, Sakpuwadol N, Yongpisarn T, Pomsoong C, Namasondhi A, Rattananukrom T, Thadanipon K. Efficacy of Combined 595-nm Pulsed Dye Laser and Intralesional Corticosteroids Versus Intralesional Corticosteroids Alone for Treating Postmastectomy Hypertrophic Scars and Keloids in Transgender Men: A Randomized Controlled Trial. J Cosmet Dermatol. 2025 Mar;24(3):e70029. doi: 10.1111/jocd.70029. PMID: 40035347; PMCID: PMC11877627. 4: Miyake K, Egawa M, Mitamura Y, Yanai R. Case report: Two cases of multiple evanescent white dot syndrome with transient night blindness. Front Ophthalmol (Lausanne). 2025 Feb 17;5:1557294. doi: 10.3389/fopht.2025.1557294. PMID: 40034237; PMCID: PMC11873098. 5: Nanda R, Jabeen A, Raina B, Garg G, Kapoor B. Management of Tubercular Retinal Vasculitis: A Case Report From an Endemic Region. Cureus. 2025 Jan 29;17(1):e78167. doi: 10.7759/cureus.78167. PMID: 40026948; PMCID: PMC11870784. 6: Yuan Y, Zhang S, Hu D, Wang B, Li Y. Efficacy of triamcinolone acetonide combined with recombinant bovine basic fibroblast growth factor in preventing scar formation after adult circumcision using a stapler device: A randomized controlled trial. Medicine (Baltimore). 2025 Feb 28;104(9):e41500. doi: 10.1097/MD.0000000000041500. PMID: 40020146; PMCID: PMC11875566. 7: Mardhiah J, Halim AS, Heng S, Saipolamin AQ. Scoping review for pain mitigation during intralesional injections of corticosteroid for hypertrophic scar and keloid treatment. BMJ Open. 2025 Feb 26;15(2):e092800. doi: 10.1136/bmjopen-2024-092800. PMID: 40010838; PMCID: PMC11865806. 8: Xia JL, Lai JM, Palestine AG, Reddy AK. Epstein-Barr Virus Associated Frosted Branch Angiitis. Retin Cases Brief Rep. 2025 Feb 21. doi: 10.1097/ICB.0000000000001742. Epub ahead of print. PMID: 40009828. 9: Ghorbanpour S, Abdi M, Naeemi N, Rahimibarghani S, Hosseini M, Emami Razavi SZ, Azadvari M. Hydrodissection With or Without Corticosteroid Versus Corticosteroid-Only Injection for Carpal Tunnel Syndrome: Double-Blind Randomized Controlled Trial. Muscle Nerve. 2025 Feb 26. doi: 10.1002/mus.28382. Epub ahead of print. PMID: 40007483. 10: Lee JY, Kim MS. Treatment with Subtenon and Intravitreal Triamcinolone Acetonide for Cystoid Macular Edema after Cytomegalovirus Retinitis. Korean J Ophthalmol. 2025 Feb 26. doi: 10.3341/kjo.2024.0086. Epub ahead of print. PMID: 40007193. 11: Błochowiak K, Kraiz A, Bowszyc-Dmochowska M, Paszyńska E, Jenerowicz D. Miescher's Cheilitis as a Diagnostic and Therapeutic Challenge-A Case Report. Medicina (Kaunas). 2025 Feb 9;61(2):299. doi: 10.3390/medicina61020299. PMID: 40005416; PMCID: PMC11857799. 12: Hoseininejad SS, Rahbar R, Farhadi M, Godarzi S. Comparative Evaluation of Intralesional Injection of Botulinum Toxin Type A versus Triamcinolone Acetonide in Treating Post-Burn Pruritus. Maedica (Bucur). 2024 Dec;19(4):763-768. doi: 10.26574/maedica.2024.19.4.763. PMID: 39974458; PMCID: PMC11834847. 13: Hirai C, Shiraishi E, Tsuchida H, Shinoda K. Development of Age-Related Macular Degeneration During Treatment for Diabetic Macular Edema: A Case Report. Cureus. 2025 Jan 18;17(1):e77606. doi: 10.7759/cureus.77606. PMID: 39963624; PMCID: PMC11831238. 14: Miyake T, Kimura N, Gomi F. Bilateral Foveal Damage Induced by Indirect Picosecond Nd:YAG Laser Exposure: A Case Report. Case Rep Ophthalmol Med. 2025 Feb 7;2025:6664488. doi: 10.1155/crop/6664488. PMID: 39958257; PMCID: PMC11828650. 15: Ng HI, Liu Y, Liu Y, Dou LZ, He S, Wang GQ. Endoscopic radial incision combined with local injection of triamcinolone acetonide for refractory esophageal stenosis after endoscopy submucosal dissection. Updates Surg. 2025 Feb 13. doi: 10.1007/s13304-025-02069-5. Epub ahead of print. PMID: 39948302. 16: Nurkan M, Eijgen JV, De Clerck I, Stalmans I, Barbosa-Breda J. The effect of inner limiting membrane peeling on visual fields: Unravelling a source of bias in glaucoma management. Saudi J Ophthalmol. 2024 Sep 16;38(4):332-342. doi: 10.4103/sjopt.sjopt_156_24. PMID: 39943945; PMCID: PMC11811406. 17: Huang Z, Xu M, Zhang W, Song X. Triamcinolone acetonide and botulinum toxin A for upper eyelid retraction in thyroid-associated ophthalmopathy. Sci Rep. 2025 Feb 11;15(1):5103. doi: 10.1038/s41598-025-89063-4. PMID: 39934153; PMCID: PMC11814297. 18: Momenaei B, Pandit SA, Wang KY, Wakabayashi T, Hsu J, Regillo CD, Klufas MA, Xu D, Cohen MN, Garg SJ, Kuriyan AE, Yonekawa Y. REPLY TO "CORRESPONDENCE REGARDING THE ARTICLE SUPRACHOROIDAL TRIAMCINOLONE ACETONIDE FOR REFRACTORY POSTOPERATIVE CYSTOID MACULAR EDEMA". Retina. 2025 Feb 6. doi: 10.1097/IAE.0000000000004423. Epub ahead of print. PMID: 39933134. 19: Joshi N, Vaidya M, Mehta P, Subramanyam A. CORRESPONDENCE REGARDING THE ARTICLE "SUPRACHOROIDAL TRIAMCINOLONE ACETONIDE FOR REFRACTORY POSTOPERATIVE CYSTOID MACULAR EDEMA". Retina. 2025 Feb 6. doi: 10.1097/IAE.0000000000004422. Epub ahead of print. PMID: 39933121. 20: Nauman A, Iqbal K, Seyal M. Effect of Suprachoroidal Triamcinolone Acetonide on Intraocular Pressure in Macular Edema: A Retrospective Study. Cureus. 2025 Jan 11;17(1):e77282. doi: 10.7759/cureus.77282. PMID: 39931603; PMCID: PMC11809668.