SB-747651A | CAS#607372-46-3 |MSK1 Inhibitor

MedKoo Cat#: 532680 | Name: SB-747651A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SB-747651A is a potent, ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor (IC50 = 11 nM in an in vitro kinase assay). It targets the N-terminal kinase domain. SB-747651A inhibits MSK1, MSK2, PKA, PKB, RSK and p70S6K activity in cells.

Chemical Structure

SB-747651A

CAS#607372-46-3 (free base)

Theoretical Analysis

MedKoo Cat#: 532680

Name: SB-747651A

CAS#: 607372-46-3 (free base)

Chemical Formula: C16H22N8O

Exact Mass: 342.1917

Molecular Weight: 342.41

Elemental Analysis: C, 56.13; H, 6.48; N, 32.73; O, 4.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

607372-46-3 (free base) 1781882-72-1 (HCl)

Synonym

SB-747651A; SB 747651A; SB747651A.

IUPAC/Chemical Name

N-[[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[5,4-d]pyridin-7-yl]methyl]piperidin-4-amine

InChi Key

MBCJUIJWPYUEBX-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H22N8O/c1-2-24-14-10(8-20-11-3-5-18-6-4-11)7-19-9-12(14)21-16(24)13-15(17)23-25-22-13/h7,9,11,18,20H,2-6,8H2,1H3,(H2,17,23)

SMILES Code

CCN1C(C2=NON=C2N)=NC3=CN=CC(CNC4CCNCC4)=C31

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 342.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhao C, Hui W, Fernandes MJ, Poubelle PE, Bourgoin SG. Lysophosphatidic acid-induced IL-8 secretion involves MSK1 and MSK2 mediated activation of CREB1 in human fibroblast-like synoviocytes. Biochem Pharmacol. 2014 Jul 1;90(1):62-72. doi: 10.1016/j.bcp.2014.04.012. Epub 2014 Apr 30. PubMed PMID: 24792438. 2: Johnson J, Shi Z, Liu Y, Stack MS. Inhibitors of NF-kappaB reverse cellular invasion and target gene upregulation in an experimental model of aggressive oral squamous cell carcinoma. Oral Oncol. 2014 May;50(5):468-77. doi: 10.1016/j.oraloncology.2014.02.004. Epub 2014 Feb 28. PubMed PMID: 24582884; PubMed Central PMCID: PMC4001858. 3: Naqvi S, Macdonald A, McCoy CE, Darragh J, Reith AD, Arthur JS. Characterization of the cellular action of the MSK inhibitor SB-747651A. Biochem J. 2012 Jan 1;441(1):347-57. doi: 10.1042/BJ20110970. PubMed PMID: 21970321.