LASSBio-881 | CAS# | CB1 and CB2 cannabinoid receptor

MedKoo Cat#: 522702 | Name: LASSBio-881

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LASSBio-881 is a drug which acts as both a non-selective partial agonist of the CB1 and CB2 cannabinoid receptors, and also as an antagonist of the TRPV1 receptor, as well as having antioxidant effects. It has potent anti-inflammatory and anti-hyperalgesic effects in animal studies.

Chemical Structure

LASSBio-881

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 522702

Name: LASSBio-881

CAS#: unknown

Chemical Formula: C23H27N3O6

Exact Mass: 441.1900

Molecular Weight: 441.48

Elemental Analysis: C, 62.57; H, 6.16; N, 9.52; O, 21.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

LASSBio-881; LASSBio 881; LASSBio881.

IUPAC/Chemical Name

N'-[(3,5-ditert-butyl-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-6-nitro-1,3-benzodioxole-5-carbohydrazide

InChi Key

YLCSFBMOLIJBHG-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H27N3O6/c1-22(2,3)15-7-13(8-16(20(15)27)23(4,5)6)11-24-25-21(28)14-9-18-19(32-12-31-18)10-17(14)26(29)30/h7-11,24H,12H2,1-6H3,(H,25,28)

SMILES Code

O=C(C1=C([N+]([O-])=O)C=C(OCO2)C2=C1)NN/C=C3C=C(C(C)(C)C)C(C(C(C)(C)C)=C/3)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 441.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Salat K, Moniczewski A, Librowski T. Nitrogen, oxygen or sulfur containing heterocyclic compounds as analgesic drugs used as modulators of the nitroxidative stress. Mini Rev Med Chem. 2013 Mar;13(3):335-52. Review. PubMed PMID: 22876956. 2: Tributino JL, Santos ML, Mesquita CM, Lima CK, Silva LL, Maia RC, Duarte CD, Barreiro EJ, Fraga CA, Castro NG, Miranda AL, Guimaraes MZ. LASSBio-881: an N-acylhydrazone transient receptor potential vanilloid subfamily type 1 antagonist orally effective against the hypernociception induced by capsaicin or partial sciatic ligation. Br J Pharmacol. 2010 Apr;159(8):1716-23. PubMed PMID: 20401963; PubMed Central PMCID: PMC2925494. 3: Duarte CD, Tributino JL, Lacerda DI, Martins MV, Alexandre-Moreira MS, Dutra F, Bechara EJ, De-Paula FS, Goulart MO, Ferreira J, Calixto JB, Nunes MP, Bertho AL, Miranda AL, Barreiro EJ, Fraga CA. Synthesis, pharmacological evaluation and electrochemical studies of novel 6-nitro-3,4-methylenedioxyphenyl-N-acylhydrazone derivatives: Discovery of LASSBio-881, a new ligand of cannabinoid receptors. Bioorg Med Chem. 2007 Mar 15;15(6):2421-33. Epub 2007 Jan 17. PubMed PMID: 17275312.