SB 258719 HCl | CAS#1217674-10-6|195199-95-2 | 5-HT7 receptor antagonist

MedKoo Cat#: 532659 | Name: SB 258719 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SB 258719 HCl is a selective 5-HT7 receptor antagonist that displays > 100-fold selectivity over a range of other receptors. It reverses the hypothermic effect of 5-CT in mice following i.p. administration.

Chemical Structure

SB 258719 HCl

CAS#1217674-10-6 (SB 258719 HCl), 195199-95-2 (SB258719)

Theoretical Analysis

MedKoo Cat#: 532659

Name: SB 258719 HCl

CAS#: 1217674-10-6 (SB 258719 HCl), 195199-95-2 (SB258719)

Chemical Formula: C18H31ClN2O2S

Exact Mass:

Molecular Weight: 374.97

Elemental Analysis: C, 57.66; H, 8.33; Cl, 9.45; N, 7.47; O, 8.53; S, 8.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1217674-10-6 (SB 258719 HCl) 195199-95-2 (SB258719)

Synonym

SB 258719; SB-258719; SB258719; SB 258719 HCl.

IUPAC/Chemical Name

N,3-dimethyl-N-[(2R)-4-(4-methylpiperidin-1-yl)butan-2-yl]benzenesulfonamide Hydrochloride

InChi Key

UIZKHTBWJSUGOV-UNTBIKODSA-N

InChi Code

InChI=1S/C18H30N2O2S.ClH/c1-15-8-11-20(12-9-15)13-10-17(3)19(4)23(21,22)18-7-5-6-16(2)14-18;/h5-7,14-15,17H,8-13H2,1-4H3;1H/t17-;/m1./s1

SMILES Code

O=S(C1=CC=CC(C)=C1)(N(C)[C@@H](CCN2CCC(C)CC2)C)=O.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 374.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mahé C, Loetscher E, Feuerbach D, Müller W, Seiler MP, Schoeffter P. Differential inverse agonist efficacies of SB-258719, SB-258741 and SB-269970 at human recombinant serotonin 5-HT7 receptors. Eur J Pharmacol. 2004 Jul 14;495(2-3):97-102. PubMed PMID: 15249157. 2: Thomas DR, Gittins SA, Collin LL, Middlemiss DN, Riley G, Hagan J, Gloger I, Ellis CE, Forbes IT, Brown AM. Functional characterisation of the human cloned 5-HT7 receptor (long form); antagonist profile of SB-258719. Br J Pharmacol. 1998 Jul;124(6):1300-6. PubMed PMID: 9720804; PubMed Central PMCID: PMC1565501.