RU28318 potassium | CAS#76676-34-1 |786592-95-8

MedKoo Cat#: 532597 | Name: RU28318 potassium

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

RU 28318, potassium salt is a potent and selective antagonist for the mineralocorticoid receptor (MR). RU 28318, potassium salt inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. It also decreases blood pressure in female rats following central administration in vivo.

Chemical Structure

RU28318 potassium

CAS#76676-34-1 (potassium)

Theoretical Analysis

MedKoo Cat#: 532597

Name: RU28318 potassium

CAS#: 76676-34-1 (potassium)

Chemical Formula: C25H37KO4

Exact Mass: 0.0000

Molecular Weight: 440.66

Elemental Analysis: C, 68.14; H, 8.46; K, 8.87; O, 14.52

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 365.00
50mg	USD 1,350.00

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Related CAS #

76676-34-1 (potassium) 786592-95-8 (free acid)

Synonym

RU28318; RU 28318; RU-28318; RU 28318, potassium salt.

IUPAC/Chemical Name

potassium 3-((7R,8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-3-oxo-7-propyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)propanoate

InChi Key

HXJITUGMCJCKCE-NKTBGYRQSA-M

InChi Code

InChI=1S/C25H38O4.K/c1-4-5-16-14-17-15-18(26)6-10-23(17,2)19-7-11-24(3)20(22(16)19)8-12-25(24,29)13-9-21(27)28;/h15-16,19-20,22,29H,4-14H2,1-3H3,(H,27,28);/q;+1/p-1/t16-,19+,20+,22-,23+,24+,25+;/m1./s1

SMILES Code

C[C@@]12[C@](CCC([O-])=O)(O)CC[C@@]1([H])[C@]3([H])[C@H](CCC)CC4=CC(CC[C@]4(C)[C@@]3([H])CC2)=O.[K+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 440.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Glucocorticoid mediates water avoidance stress-sensitized colon-bladder cross-talk via RSK2/PSD-95/NR2B in rats. Am J Physiol Endocrinol Metab. 2012 Nov 1;303(9):E1094-106. doi: 10.1152/ajpendo.00235.2012. PMID: 23125098. 11: Dorey R, Piérard C, Chauveau F, David V, Béracochéa D. Stress-induced memory retrieval impairments: different time-course involvement of corticosterone and glucocorticoid receptors in dorsal and ventral hippocampus. Neuropsychopharmacology. 2012 Dec;37(13):2870-80. doi: 10.1038/npp.2012.170. Epub 2012 Sep 5. PMID: 22948976; PMCID: PMC3499833. 12: Zhang ZH, Yu Y, Wei SG, Felder RB. Aldosterone-induced brain MAPK signaling and sympathetic excitation are angiotensin II type-1 receptor dependent. Am J Physiol Heart Circ Physiol. 2012 Feb 1;302(3):H742-51. doi: 10.1152/ajpheart.00856.2011. Epub 2011 Nov 11. PMID: 22081704; PMCID: PMC3353800. 13: Jadavji NM, Supina RD, Metz GA. 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