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MedKoo Cat#: 565792 | Name: KC-11

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KC-11 is a novel selective inhibitor of mtb-dhfr

Chemical Structure

KC-11
KC-11
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 565792

Name: KC-11

CAS#: N/A

Chemical Formula: C27H23BrN4O2

Exact Mass: 514.1004

Molecular Weight: 515.41

Elemental Analysis: C, 62.92; H, 4.50; Br, 15.50; N, 10.87; O, 6.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
KC-11; KC 11; KC11
IUPAC/Chemical Name
1-(1-Benzyl-5-((1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-2-methyl-1H-indol-3-yl)ethan-1-one
InChi Key
SJXBIRVGNOAQRT-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H23BrN4O2/c1-18-27(19(2)33)25-14-24(12-13-26(25)31(18)15-20-6-4-3-5-7-20)34-17-22-16-32(30-29-22)23-10-8-21(28)9-11-23/h3-14,16H,15,17H2,1-2H3
SMILES Code
CC(C1=C(C)N(CC2=CC=CC=C2)C3=C1C=C(OCC4=CN(C5=CC=C(Br)C=C5)N=N4)C=C3)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 515.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ring E, Johansson J, Sandström C, Bjarnadóttir B, Finér L, Lībiete Z, Lode E, Stupak I, Sætersdal M. Mapping policies for surface water protection zones on forest land in the Nordic-Baltic region: Large differences in prescriptiveness and zone width. Ambio. 2017 Dec;46(8):878-893. doi: 10.1007/s13280-017-0924-8. Epub 2017 Jun 1. PubMed PMID: 28573599; PubMed Central PMCID: PMC5639796. 2: Sharma K, Tanwar O, Deora GS, Ali S, Alam MM, Zaman MS, Krishna VS, Sriram D, Akhter M. Expansion of a novel lead targeting M. tuberculosis DHFR as antitubercular agents. Bioorg Med Chem. 2019 Apr 1;27(7):1421-1429. doi: 10.1016/j.bmc.2019.02.053. Epub 2019 Feb 26. PubMed PMID: 30827867.