JHU 37160 is a high affinity and highly potent activator of hM3Dq and hM4Di DREADDs. It displays approximately 25-fold higher affinity for hM4Di compared to DREADD agonist 21. It selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites. JHU 37160 inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons, and increases hM3Dq-stimulated locomotion in rats expressing hM3Dq in TH-expressing neurons. It is a brain penetrant in mice, rats and non-human primates.
MedKoo Cat#: 463296
Name: JHU 37160
CAS#: 2369979-68-8
Chemical Formula: C19H20ClFN4
Exact Mass: 358.1361
Molecular Weight: 358.85
Elemental Analysis: C, 63.60; H, 5.62; Cl, 9.88; F, 5.29; N, 15.61
The following data is based on the product molecular weight 358.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
