VK-II-86 is a synthetic analogue of carvedilol that lacks β-adrenoceptor antagonist activity. It targets the ryanodine receptor 2 (RyR2) channel, inhibiting store-overload-induced calcium release (SOICR). Therapeutically, VK-II-86 has been shown to prevent hypokalaemia-induced ventricular arrhythmias by normalizing calcium homeostasis and repolarization reserve. Additionally, it has demonstrated efficacy in reducing ouabain-induced apoptosis and spontaneous contractions in cardiac myocytes, indicating potential in treating digitalis-induced arrhythmias.
MedKoo Cat#: 122964
Name: VK-II-86
CAS#: 955371-84-3
Chemical Formula: C25H28N2O4
Exact Mass: 420.2049
Molecular Weight: 420.51
Elemental Analysis: C, 71.41; H, 6.71; N, 6.66; O, 15.22
The following data is based on the product molecular weight 420.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
