RS-102895 HCl is a CCR2-selective chemokine receptor antagonist (IC50 values are 0.36 and 17.8 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). RS-102895 HCl blocks MCP-1-stimulated calcium influx and chemotaxis with IC50 values of 32 nM and 1.7 μM respectively. It also inhibits α1A, α1D and 5-HT1A receptors.
MedKoo Cat#: 532582
Name: RS-102895 HCl
CAS#: 1173022-16-6 (RS-102895 HCl); 300815-41-2(RS-102895).
Chemical Formula: C21H22ClF3N2O2
Exact Mass:
Molecular Weight: 426.86
Elemental Analysis: C, 59.09; H, 5.20; Cl, 8.30; F, 13.35; N, 6.56; O, 7.50
The following data is based on the product molecular weight 426.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
