Eilatine | CAS#120154-96-3 | Progenitor cell proliferation inhibitor

MedKoo Cat#: 463901 | Name: Eilatine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Eilatine is a novel marine alkaloid inhibits in vitro proliferation of progenitor cells in chronic myeloid leukemia patients.

Chemical Structure

Eilatine

CAS#120154-96-3

Theoretical Analysis

MedKoo Cat#: 463901

Name: Eilatine

CAS#: 120154-96-3

Chemical Formula: C24H12N4

Exact Mass: 356.1062

Molecular Weight: 356.39

Elemental Analysis: C, 80.88; H, 3.39; N, 15.72

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Eilatine; Eilatin;

IUPAC/Chemical Name

dibenzo[b,j]dipyrido[4,3,2-de:2',3',4'-gh][1,10]phenanthroline

InChi Key

XLONQTAYDCFVPP-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H12N4/c1-3-7-17-13(5-1)15-9-11-25-21-19(15)23(27-17)24-20-16(10-12-26-22(20)21)14-6-2-4-8-18(14)28-24/h1-12H

SMILES Code

c1(ccccc1nc2c(nc3c4cccc3)c5c4ccnc65)c7c2c6ncc7

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 356.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Bouffier L, Dinica R, Debray J, Dumy P, Demeunynck M. Functionalization of the A ring of pyridoacridine as a route toward greater structural diversity. Synthesis of an octacyclic analogue of eilatin. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4836-8. doi: 10.1016/j.bmcl.2009.06.039. Epub 2009 Jun 13. PMID: 19559608. 2: Bergman SD, Goldberg I, Barbieri A, Kol M. Mononuclear and dinuclear complexes of isoeilatin. Inorg Chem. 2005 Apr 4;44(7):2513-23. doi: 10.1021/ic050002q. PMID: 15792490. 3: Bergman SD, Reshef D, Frish L, Cohen Y, Goldberg I, Kol M. From eilatin to isoeilatin: a skeletal rearrangement strongly influences pi-stacking of Ru(II) complex. Inorg Chem. 2004 Jun 28;43(13):3792-4. doi: 10.1021/ic049806g. PMID: 15206856. 4: Luedtke NW, Hwang JS, Nava E, Gut D, Kol M, Tor Y. The DNA and RNA specificity of eilatin Ru(II) complexes as compared to eilatin and ethidium bromide. Nucleic Acids Res. 2003 Oct 1;31(19):5732-40. doi: 10.1093/nar/gkg758. PMID: 14500837; PMCID: PMC206458. 5: Luedtke NW, Tor Y. Fluorescence-based methods for evaluating the RNA affinity and specificity of HIV-1 Rev-RRE inhibitors. Biopolymers. 2003 Sep;70(1):103-19. doi: 10.1002/bip.10428. PMID: 12925996. 6: Gut D, Goldberg I, Kol M. Eilatin as a bridging ligand in ruthenium(II) complexes: synthesis, crystal structures, absorption spectra, and electrochemical properties. Inorg Chem. 2003 Jun 2;42(11):3483-91. doi: 10.1021/ic020703c. PMID: 12767184. 7: Luedtke NW, Hwang JS, Glazer EC, Gut D, Kol M, Tor Y. Eilatin Ru(II) complexes display anti-HIV activity and enantiomeric diversity in the binding of RNA. Chembiochem. 2002 Aug 2;3(8):766-71. doi: 10.1002/1439-7633(20020802)3:8<766::AID-CBIC766>3.0.CO;2-X. PMID: 12203975. 8: Gut D, Rudi A, Kopilov J, Goldberg I, Kol M. Pairing of propellers: dimerization of octahedral ruthenium(II) and osmium(II) complexes of eilatin via pi-pi stacking featuring heterochiral recognition. J Am Chem Soc. 2002 May 15;124(19):5449-56. doi: 10.1021/ja012636b. PMID: 11996586. 9: Toren A, Einat M, Fabian I, Nagler A. Human umbilical cord blood myeloid progenitor cells are relatively chemoresistant: a potential model for autologous transplantations in HIV-infected newborns. Am J Hematol. 1997 Nov;56(3):161-7. doi: 10.1002/(sici)1096-8652(199711)56:3<161::aid-ajh5>3.0.co;2-w. PMID: 9371528. 10: Einat M, Nagler A, Amiel A, Fejgin MD, Rudi A, Kashman Y, Fabian I. Synergistic effects of interleukin-11 with other growth factors on the expansion of hematopoietic progenitors from normal individuals and chronic myeloid leukemia patients resistant to treatment with cytosine arabinoside or eilatin. Leuk Res. 1996 Sep;20(9):751-9. doi: 10.1016/0145-2126(96)00039-2. PMID: 8947585. 11: Einat M, Lishner M, Amiel A, Nagler A, Yarkorli S, Rudi A, Kashman Y, Markel D, Fabian I. Eilatin: a novel marine alkaloid inhibits in vitro proliferation of progenitor cells in chronic myeloid leukemia patients. Exp Hematol. 1995 Dec;23(14):1439-44. PMID: 8542929.