Ro 04-6790 | CAS#202466-68-0 | 5-HT6 receptor Antagonist

MedKoo Cat#: 532547 | Name: Ro 04-6790

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro 04-6790 is a potent and selective 5-HT6 receptor antagonist (pKi values are 7.26 and 7.35 at rat and human 5-HT6 receptors respectively). Ro 04-6790 displays no affinity at a range of other receptors (IC50 > 10 μM).

Chemical Structure

Ro 04-6790

CAS#202466-68-0 (free base)

Theoretical Analysis

MedKoo Cat#: 532547

Name: Ro 04-6790

CAS#: 202466-68-0 (free base)

Chemical Formula: C12H16N6O2S

Exact Mass: 308.1055

Molecular Weight: 308.36

Elemental Analysis: C, 46.74; H, 5.23; N, 27.25; O, 10.38; S, 10.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

202466-68-0 (free base) 1197333-95-1 (dihydrochloride)

Synonym

Ro 04-6790; Ro04-6790; Ro-04-6790.

IUPAC/Chemical Name

4-amino-N-[2,6-bis(methylamino)pyrimidin-4-yl]benzenesulfonamide

InChi Key

JELFWSXQTXRMAJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18)

SMILES Code

O=S(C1=CC=C(N)C=C1)(NC2=NC(NC)=NC(NC)=C2)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 308.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Thur KE, Nelson AJ, Cassaday HJ. Ro 04-6790-induced cognitive enhancement: no effect in trace conditioning and novel object recognition procedures in adult male Wistar rats. Pharmacol Biochem Behav. 2014 Dec;127:42-8. doi: 10.1016/j.pbb.2014.10.006. Epub 2014 Oct 24. PubMed PMID: 25450117; PubMed Central PMCID: PMC4258611. 2: King MV, Spicer CH, Sleight AJ, Marsden CA, Fone KC. Impact of regional 5-HT depletion on the cognitive enhancing effects of a typical 5-ht(6) receptor antagonist, Ro 04-6790, in the Novel Object Discrimination task. Psychopharmacology (Berl). 2009 Jan;202(1-3):111-23. doi: 10.1007/s00213-008-1334-1. Epub 2008 Oct 7. PubMed PMID: 18839151. 3: Pitsikas N, Zisopoulou S, Pappas I, Sakellaridis N. The selective 5-HT(6) receptor antagonist Ro 04-6790 attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801. Behav Brain Res. 2008 Apr 9;188(2):304-9. doi: 10.1016/j.bbr.2007.11.010. Epub 2007 Nov 21. PubMed PMID: 18164078. 4: Woolley ML, Marsden CA, Sleight AJ, Fone KC. Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790. Psychopharmacology (Berl). 2003 Dec;170(4):358-67. Epub 2003 Sep 10. PubMed PMID: 13680084. 5: Meneses A. Effects of the 5-HT(6) receptor antagonist Ro 04-6790 on learning consolidation. Behav Brain Res. 2001 Jan 8;118(1):107-10. PubMed PMID: 11163639. 6: Bentley JC, Bourson A, Boess FG, Fone KC, Marsden CA, Petit N, Sleight AJ. Investigation of stretching behaviour induced by the selective 5-HT6 receptor antagonist, Ro 04-6790, in rats. Br J Pharmacol. 1999 Apr;126(7):1537-42. PubMed PMID: 10323584; PubMed Central PMCID: PMC1565929. 7: Sleight AJ, Boess FG, Bös M, Levet-Trafit B, Riemer C, Bourson A. Characterization of Ro 04-6790 and Ro 63-0563: potent and selective antagonists at human and rat 5-HT6 receptors. Br J Pharmacol. 1998 Jun;124(3):556-62. PubMed PMID: 9647481; PubMed Central PMCID: PMC1565407.