S107 free base | CAS#927871-76-9 | RyR1 stabilizer

MedKoo Cat#: 530577 | Name: S107 free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

S107 is a Type 1 ryanodine receptor (RyR1) stabilizer; binds RyR1 and enhances the binding affinity of calstabin-1. Inhibits Ca leak from the sarcoplasmic reticulum (SR). S107 has therapeutic potential in the management of RBM20 cardiomyopathy.

Chemical Structure

S107 free base

CAS#927871-76-9 (free base)

Theoretical Analysis

MedKoo Cat#: 530577

Name: S107 free base

CAS#: 927871-76-9 (free base)

Chemical Formula: C11H15NOS

Exact Mass: 209.0874

Molecular Weight: 209.31

Elemental Analysis: C, 63.12; H, 7.22; N, 6.69; O, 7.64; S, 15.32

Price and Availability

Size	Price	Availability
100mg	USD 750.00	2 Weeks
200mg	USD 1,250.00	2 Weeks
500mg	USD 1,950.00	2 Weeks
1g	USD 3,250.00	2 Weeks
2g	USD 4,750.00	2 Weeks
5g	USD 7,850.00	2 Weeks

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Related CAS #

1357476-46-0 (HCl) 927871-76-9 (free base)

Synonym

S107; S-107; S 107.

IUPAC/Chemical Name

2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine

InChi Key

BGVCEGVSQDOGSB-UHFFFAOYSA-N

InChi Code

InChI=1S/C11H15NOS/c1-12-5-6-14-11-4-3-10(13-2)7-9(11)8-12/h3-4,7H,5-6,8H2,1-2H3

SMILES Code

CN1CCSC2=CC=C(OC)C=C2C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 209.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Retraction. J Cell Biochem. 2021 Nov;122 Suppl 1:S107. doi: 10.1002/jcb.30087. Epub 2021 Jul 21. PMID: 34289164. 2: Guo W, Zhu C, Yin Z, Zhang Y, Wang C, Walk AS, Lin YH, McKinsey TA, Woulfe KC, Ren J, Chew HG Jr. The ryanodine receptor stabilizer S107 ameliorates contractility of adult Rbm20 knockout rat cardiomyocytes. Physiol Rep. 2021 Sep;9(17):e15011. doi: 10.14814/phy2.15011. PMID: 34523260; PMCID: PMC8440945. 3: Dridi H, Liu Y, Reiken S, Liu X, Argyrousi EK, Yuan Q, Miotto MC, Sittenfeld L, Meddar A, Soni RK, Arancio O, Lacampagne A, Marks AR. Heart failure-induced cognitive dysfunction is mediated by intracellular Ca2+ leak through ryanodine receptor type 2. Nat Neurosci. 2023 Aug;26(8):1365-1378. doi: 10.1038/s41593-023-01377-6. Epub 2023 Jul 10. PMID: 37429912; PMCID: PMC10400432. 4: Keilhoff G, Pinkernelle J, Fansa H. The Ryanodine receptor stabilizer S107 fails to support motor neuronal neuritogenesis in vitro. Tissue Cell. 2021 Dec;73:101625. doi: 10.1016/j.tice.2021.101625. Epub 2021 Aug 17. PMID: 34419737. 5: Cook WD, Rudikoff S, Giusti AM, Zack DJ, Kelly T, Scharff MD. Antigen binding variants of the S107 mouse myeloma cell line. Prog Clin Biol Res. 1980;42:217-30. PMID: 6771769. 6: Dislocations. J Orthop Trauma. 2018 Jan;32 Suppl 1:S107-S116. doi: 10.1097/BOT.0000000000001057. PMID: 29256960. 7: Liu Y, Reiken S, Dridi H, Yuan Q, Mohammad KS, Trivedi T, Miotto MC, Wedderburn-Pugh K, Sittenfeld L, Kerley Y, Meyer JA, Peters JS, Persohn SC, Bedwell AA, Figueiredo LL, Suresh S, She Y, Soni RK, Territo PR, Marks AR, Guise TA. Targeting ryanodine receptor type 2 to mitigate chemotherapy-induced neurocognitive impairments in mice. Sci Transl Med. 2023 Sep 27;15(715):eadf8977. doi: 10.1126/scitranslmed.adf8977. Epub 2023 Sep 27. PMID: 37756377. 8: Pennell CA. Selection for S107-V11 gene expression by peritoneal B cells in adult mice. J Immunol. 1995 Aug 1;155(3):1264-75. PMID: 7636194. 9: Hidisoglu E, Chiantia G, Franchino C, Tomagra G, Giustetto M, Carbone E, Carabelli V, Marcantoni A. The ryanodine receptor-calstabin interaction stabilizer S107 protects hippocampal neurons from GABAergic synaptic alterations induced by Abeta42 oligomers. J Physiol. 2022 Dec;600(24):5295-5309. doi: 10.1113/JP283537. Epub 2022 Nov 15. PMID: 36284365. 10: Erratum Regarding "KDOQI Clinical Practice Guideline for Nutrition in CKD: 2020 Update" (Am J Kidney Dis. 2020;76[3][suppl 1]:S1-S107). Am J Kidney Dis. 2021 Feb;77(2):308. doi: 10.1053/j.ajkd.2020.11.004. Epub 2020 Nov 21. Erratum for: Am J Kidney Dis. 2020 Sep;76(3 Suppl 1):S1-S107. doi: 10.1053/j.ajkd.2020.05.006. PMID: 33229127. 11: Behar SM, Scharff MD. Somatic diversification of the S107 (T15) VH11 germ- line gene that encodes the heavy-chain variable region of antibodies to double- stranded DNA in (NZB x NZW)F1 mice. Proc Natl Acad Sci U S A. 1988 Jun;85(11):3970-4. doi: 10.1073/pnas.85.11.3970. PMID: 3131767; PMCID: PMC280342. 12: Mei Y, Xu L, Kramer HF, Tomberlin GH, Townsend C, Meissner G. Stabilization of the skeletal muscle ryanodine receptor ion channel-FKBP12 complex by the 1,4-benzothiazepine derivative S107. PLoS One. 2013;8(1):e54208. doi: 10.1371/journal.pone.0054208. Epub 2013 Jan 17. PMID: 23349825; PMCID: PMC3547879. 13: Jackson A. Image processing. Br J Radiol. 2004;77 Spec No 2:S107. doi: 10.1259/bjr/23442591. PMID: 15677351. 14: Atchley P, Strayer DL. Small Screen Use and Driving Safety. Pediatrics. 2017 Nov;140(Suppl 2):S107-S111. doi: 10.1542/peds.2016-1758M. PMID: 29093043. 15: Liao PL, Wei CY. Letter to the Editor: Comment on Chen SH, et al. End-to- side Anterior Interosseous Nerve Transfer: A Valuable Alternative for Traumatic High Ulnar Nerve Palsy ( Ann Plast Surg . 2021;86(suppl 1):S102-S107). Ann Plast Surg. 2022 Sep 1;89(3):337. doi: 10.1097/SAP.0000000000003013. Epub 2021 Oct 8. PMID: 34670975. 16: Joseph DA, DeGroff A. The CDC Colorectal Cancer Control Program, 2009-2015. Prev Chronic Dis. 2019 Dec 5;16:E159. doi: 10.5888/pcd16.190336. PMID: 31808418; PMCID: PMC6896829. 17: Kreko-Pierce T, Azpurua J, Mahoney RE, Eaton BA. Extension of Health Span and Life Span in Drosophila by S107 Requires the calstabin Homologue FK506-BP2. J Biol Chem. 2016 Dec 9;291(50):26045-26055. doi: 10.1074/jbc.M116.758839. Epub 2016 Nov 1. PMID: 27803160; PMCID: PMC5207075. 18: Giusti AM, Chien NC, Zack DJ, Shin SU, Scharff MD. Somatic diversification of S107 from an antiphosphocholine to an anti-DNA autoantibody is due to a single base change in its heavy chain variable region. Proc Natl Acad Sci U S A. 1987 May;84(9):2926-30. doi: 10.1073/pnas.84.9.2926. PMID: 3106981; PMCID: PMC304773. 19: Mohan SP, Bhaskaran MK, George AL, Thirutheri A, Somasundaran M, Pavithran A. Immunotherapy in Oral Cancer. J Pharm Bioallied Sci. 2019 May;11(Suppl 2):S107-S111. doi: 10.4103/JPBS.JPBS_31_19. PMID: 31198321; PMCID: PMC6555318. 20: Coronado F, Melvin SC, Bell RA, Zhao G. Global Responses to Prevent, Manage, and Control Cardiovascular Diseases. Prev Chronic Dis. 2022 Dec 8;19:E84. doi: 10.5888/pcd19.220347. PMID: 36480801; PMCID: PMC9746707.