Fungimycin | CAS#11016-07-2

MedKoo Cat#: 463001 | Name: Fungimycin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fungimycin is polyene antibiotic produced by Streptomyces coelicolor var. aminophilus. The compound exhibits antifungal properties.

Chemical Structure

Fungimycin

CAS#11016-07-2

Theoretical Analysis

MedKoo Cat#: 463001

Name: Fungimycin

CAS#: 11016-07-2

Chemical Formula: C59H86N2O17

Exact Mass: 1094.5926

Molecular Weight: 1095.33

Elemental Analysis: C, 64.70; H, 7.91; N, 2.56; O, 24.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

NC1968; NC-1968; NC 1968; Perimycin; Aminomycin;

IUPAC/Chemical Name

(23E,25E,27E,29E,31E,33E,35E,37Z)-22-(((3S,4S,5S,6R)-5-amino-3,4-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4,6,8,10,12,18,20-heptahydroxy-38-(5-hydroxy-7-(4-(methylamino)phenyl)-7-oxoheptan-2-yl)-19,37-dimethyloxacyclooctatriaconta-23,25,27,29,31,33,35,37-octaene-2,14,16-trione

InChi Key

QPQMKHKBRKAVRZ-FWIVLUFVSA-N

InChi Code

InChI=1S/C59H86N2O17/c1-36-18-16-14-12-10-8-6-7-9-11-13-15-17-19-50(77-59-57(75)56(74)55(60)39(4)76-59)35-52(71)38(3)51(70)33-48(68)30-46(66)28-44(64)26-43(63)27-45(65)29-47(67)31-49(69)34-54(73)78-58(36)37(2)20-25-42(62)32-53(72)40-21-23-41(61-5)24-22-40/h6-19,21-24,37-39,42-45,47,49-52,55-57,59,61-65,67,69-71,74-75H,20,25-35,60H2,1-5H3/b7-6+,10-8+,11-9+,14-12+,15-13+,18-16+,19-17+,58-36-/t37?,38?,39-,42?,43?,44?,45?,47?,49?,50?,51?,52?,55-,56+,57+,59?/m1/s1

SMILES Code

CNc1ccc(C(CC(CCC(/C2=C(/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(OC3O[C@@H]([C@H]([C@@H]([C@@H]3O)O)N)C)CC(C(C(CC(CC(CC(CC(CC(CC(CC(CC(O2)=O)O)O)O)O)O)=O)=O)O)C)O)C)C)O)=O)cc1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,095.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Geng X, Gao Y, Feng C, Guan Y. A facile and high sensitive micro fluorimeter based on light emitting diode and photodiode. Talanta. 2017 Dec 1;175:183-188. doi: 10.1016/j.talanta.2017.07.022. Epub 2017 Jul 13. PMID: 28841976. 2: Pawlak J, Sowiński P, Borowski E, Gariboldi P. Stereostructure of perimycin A. J Antibiot (Tokyo). 1995 Sep;48(9):1034-8. doi: 10.7164/antibiotics.48.1034. PMID: 7592049. 3: Cybulska B, Borowski E, Gary-Bobo CM. Relationship between ionophoric and haemolytic activities of perimycin A and vacidin A, two polyene macrolide antifungal antibiotics. Biochem Pharmacol. 1989 Jun 1;38(11):1755-62. doi: 10.1016/0006-2952(89)90409-7. PMID: 2735933. 4: Gil JA, Naharro G, Villanueva JR, Martín JF. Characterization and regulation of p-aminobenzoic acid synthase from Streptomyces griseus. J Gen Microbiol. 1985 Jun;131(6):1279-87. doi: 10.1099/00221287-131-6-1279. PMID: 3930655. 5: Liu CM, McDaniel LE, Schaffner CP. Fungimycin, biogenesis of its aromatic moiety. J Antibiot (Tokyo). 1972 Mar;25(3):187-8. doi: 10.7164/antibiotics.25.187. PMID: 5034814. 6: HEBEKA EK, SOLOTOROVSKY M. DEVELOPMENT OF RESISTANCE TO POLYENE ANTIBIOTICS IN CANDIDA ALBICANS. J Bacteriol. 1965 Jun;89(6):1533-9. doi: 10.1128/JB.89.6.1533-1539.1965. PMID: 14291593; PMCID: PMC277689. 7: MICHALSKA E. MICROBIOLOGICAL STUDIES ON N-SUCCINYL-PERIMYCIN: THE DETERMINATION OF SENSITIVITY OF CLINICAL STRAINS OF CANDIDA. Chemotherapia (Basel). 1964;9(1):52-60. doi: 10.1159/000220341. PMID: 14293427. 8: MOHAN RR, PIANOTTI RS, MARTIN JF, RINGEL SM, SCHWARTZ BS, BAILEY EG, MCDANIEL LE, SCHAFFNER CP. FUNGIMYCIN PRODUCTION, ISOLATION, BIOSYNTHESIS, AND IN VITRO ANTIFUNGAL ACTIVITY. Antimicrob Agents Chemother (Bethesda). 1963;161:462-70. PMID: 14274944.