MedKoo Cat#: 329637 | Name: Fotagliptin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fotagliptin is a novel dipeptidyl peptidase IV inhibitor under clinical development for the treatment of Type II diabetes mellitus.

Chemical Structure

Fotagliptin
Fotagliptin
CAS#312954-58-7 (free base)

Theoretical Analysis

MedKoo Cat#: 329637

Name: Fotagliptin

CAS#: 312954-58-7 (free base)

Chemical Formula: C17H19FN6O

Exact Mass: 342.1604

Molecular Weight: 342.38

Elemental Analysis: C, 59.64; H, 5.59; F, 5.55; N, 24.55; O, 4.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1403496-40-1 (benzoate) 312954-58-7 (free base)
Synonym
Fotagliptin.
IUPAC/Chemical Name
(R)-2-((3-(3-aminopiperidin-1-yl)-6-methyl-5-oxo-1,2,4-triazin-4(5H)-yl)methyl)-4-fluorobenzonitrile
InChi Key
IXSWMXRAIPXMRH-OAHLLOKOSA-N
InChi Code
InChI=1S/C17H19FN6O/c1-11-16(25)24(9-13-7-14(18)5-4-12(13)8-19)17(22-21-11)23-6-2-3-15(20)10-23/h4-5,7,15H,2-3,6,9-10,20H2,1H3/t15-/m1/s1
SMILES Code
N#CC1=CC=C(F)C=C1CN2C(N3C[C@H](N)CCC3)=NN=C(C)C2=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 342.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang Z, Jiang J, Hu P, Zhao Q. Development and validation of a UPLC-MS/MS method for simultaneous determination of fotagliptin and its two major metabolites in human plasma and urine. Bioanalysis. 2017 Feb;9(4):381-393. doi: 10.4155/bio-2016-0243. Epub 2017 Jan 19. PubMed PMID: 28102710. 2. WO2011079778.