GSK-2945 hydrochloride is an analogue of GSK 4112 which is a synthetic ligand for REV-ERBα, a member of the nuclear receptor superfamily that functions as a receptor for the porphoryin heme. GSK 4112 mimics the action of heme acting as agonist and suppresses the expression of REV-ERBα target genes involved in gluconeogenesis.
MedKoo Cat#: 574362
Name: GSK-2945 hydrochloride
CAS#: GSK-2945 HCl
Chemical Formula: C20H19Cl3N2O2S
Exact Mass: 0.0000
Molecular Weight: 457.79
Elemental Analysis: C, 52.47; H, 4.18; Cl, 23.23; N, 6.12; O, 6.99; S, 7.00
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.8 | 45.50 |
The following data is based on the product molecular weight 457.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
